A D Patil

TL;DR: As part of a search for novel inhibitors of HIV-1 reverse transcriptase, the acetone extract of the giant African snail, Achatina fulica, was shown to be active and 11 compounds of the inophyllum class were isolated, indicating certain structural requirements in the chromanol ring.

TL;DR: A MeOH/CH(2)Cl( 2) extract of the bud covers of Artocarpus altilis collected in Micronesia showed activity in a cathepsin K inhibition assay, and two new compounds have been identified whose structures were determined on the basis of spectral data.

TL;DR: TAK-981 as mentioned in this paper is a mechanism-based inhibitor of SAE which forms a SUMO-TAK-98 1 adduct as the inhibitory species within the enzyme catalytic site.

TL;DR: Bioassay-guided fractionation of the EtOAc extract of the Palauan sponge Axinyssa aplysinoides yielded two novel alkaloids, 1 and 2, which were determined by X-ray analysis and interpretation of the spectral data.

TL;DR: As part of a search for novel inhibitors of endothelin converting enzyme (ECE), the MeOH-CH2Cl2 extract of the roots of Dalea filiciformis was shown to be active and yielded a novel phytoalexin, daleformis, whose structure was determined by interpretation of spectral data and X-ray analysis.