A. Dean Sherry

TL;DR: In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

TL;DR: The goal of this article is to review the factors that govern water molecule and water proton exchange in gadolinium (III) complexes and to compare the potential sensitivity of PARACEST agents versus Gd(3+)-based T(1) relaxation agents for altering tissue contrast.

TL;DR: It is shown that glycogen can be detected indirectly through the water signal by using selective radio frequency (RF) saturation of the hydroxyl protons in the 0.5- to 1.

TL;DR: A conceptually different approach to contrast enhancement is based on chemical exchange saturation transfer (CEST), which relies on dynamic chemical exchange processes inherent in biological tissues to transfer saturated 1H spins into the bulk water proton pool, which leads to a decrease of net magnetization and is detected as a negative contrast (darkening of the image) in MRI.

TL;DR: This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism and shows that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.