A Dey

Bio: A Dey is an academic researcher from Burdwan Medical College. The author has contributed to research in topics: Medicine & Surgery. The author has an hindex of 5, co-authored 17 publications receiving 126 citations. Previous affiliations of A Dey include Chittagong Medical College Hospital & Bangladesh Council of Scientific and Industrial Research.

Fluoride Fact on Human Health and Health Problems: A Review

Abstract: Fluorine (F-) is a chemically reactive electronegative univalent gaseous halogen found in small amount in the water, air, plants and animals. Fluorine is essential for the maintenance and solidification of our bones and to prevent dental decay. It has beneficial effects on teeth and bones when it is present at low concentration in drinking water, but excessive exposure to fluoride in drinking-water, or in combination with exposure to fluoride from other sources, can give rise to a number of adverse effects which include teeth decay, osteoporosis and harm to kidney, bones, reproductive organs, nerve and muscle. Fluoride, when in excess, is known to interfere with thyroid gland function causing TSH elevation and lessen T3/T4 hormones in some populations which may be due to its antagonistic properties towards iodine. As an endocrine disruptor, F- induces more toxic outcome in diabetic patients. Chronic F- exposure through drinking water may leads to insulin resistance in humans in addition to its hyperglycemic effect due to increased hepatic glycogenolysis. Fluoride also hinders glycolysis by inhibiting enolase enzyme and repressed insulin secretion from islets of Langerhans cells resulting in elevation of blood glucose level. High F- exposure is also associated with increased levels of FSH and LH, decreased estrogen and testosterone levels, disturbed androgen to estrogen ratios (A/E) and estrogen receptor to androgen receptor ratios (ER/AR). Decreased circulating testosterone concentrations were also reported in male skeletal fluorosis patients. The most significant consequences of fluoride exposures in male reproduction are: changes in the structure and functional activities of spermatozoa and disruption of spermatogenesis while in an experimental data involving female rats showed that high fluoride concentration lowers the pregnancy rate and the number of implantation. Most interestingly, recent research showed that exposure to high concentration of F- does have deleterious effect on the mental ability of children. A strong association between exposure to fluoride and low IQ was found and it was also noted that children who live in fluorosis prevalent areas have higher chances of developing a low IQ than those who live in normal areas. So it is clear that the severity of the above pathological conditions is dependent on the dose, duration and age of the individual. Therefore, to ensure whether people need any fluoride supplements or not, government should have to take initiative to prevent health problems due to deficiency or excess fluoride exposure. Evidence-wise further thorough research is essential based on scientific facts to enlighten best practices in the use of fluoride containing materials for the safety and security of public health.

A simple theoretical analysis of the effective electron mass in III-V, ternary and quaternary materials in the presence of light waves

Abstract: We present a simple theoretical analysis of the effective electron mass (EEM) at the Fermi level for III–V, ternary and quaternary materials, on the basis of a newly formulated electron energy spectra in the presence of light waves whose unperturbed energy band structures are defined by the three-band model of Kane The solution of the Boltzmann transport equation on the basis of this newly formulated electron dispersion law will introduce new physical ideas and experimental findings under different external conditions It has been observed that the unperturbed isotropic energy spectrum in the presence of light changes into an anisotropic dispersion relation with the energy-dependent mass anisotropy In the presence of light, the conduction band moves vertically upward and the band gap increases with the intensity and colours of light It has been found, taking n-InAs, n-InSb, n-Hg1−xCdxTe and n-In1−xGaxAsyP1−y lattice matched to InP as examples, that the EEM increases with increasing electron concentration, intensity and wavelength in various manners The strong dependence of the effective momentum mass (EMM) at the Fermi level on both the light intensity and wavelength reflects the direct signature of the light waves which is in contrast with the corresponding bulk specimens of the said materials in the absence of photo-excitation The rate of change is totally band-structure-dependent and is influenced by the presence of the different energy band constants The well known result for the EEM at the Fermi level for degenerate wide gap materials in the absence of light waves has been obtained as a special case of the present analysis under certain limiting conditions, and this compatibility is the indirect test of our generalized formalism

Anti-inflammatory and Anti-tumor Activities of Parthenolide: An Update

Abstract: Parthenolide (PTL), the secondary metabolite of feverfew plant (Tanaceum parthenium), has been used in various medical purposes globally. Inflammation represents a physiological response to injury and helps to restore tissue homeostasis. Inflammation and cancer both are associated with genotoxicity, invasion, metastasis, and abnormal tissue repair mechanisms. PTL inhibit major cellular inflammatory and proliferation pathways like NFκB, STAT3, and MAPK along with the activity and expression of several inflammatory mediators including COX. NFκB pathway plays a key role in controlling cell cycle progression and apoptosis together with metastasis and cancer of various types. Elevated NFκB, Wnt/β-catenin pathways are crucial factors of tumorogenesis. PTL inhibits NFκB and Wnt/β-catenin pathways, and thereby promotes apoptosis and suppresses cell proliferation. Experimental data showed that PTL protects normal cells from apoptosis; whereas in cancer cells it induces apoptotic cell death. Hence, parthenolide could be useful in controlling inflammatory diseases alone or together with tumorogenesis due to its evident anticancer potency and anti-inflammatory nature.

Influence of Light on the Einstein Relation in Ultra-Thin Films of III-V, Ternary and Quaternary Materials: Simplified Theory, Relative Comparison and Suggestion for Experimental Determination

Abstract: In this paper, we study the Einstein relation for the diffusivity-mobility ratio (DMR) in ultra-thin films of III-V, ternary and quaternary materials in the presence of light waves, whose unperturbed energy band structures are defined by the three-band and two band models of Kane together with parabolic energy bands. The solution of the Boltzmann transport equation on the basis of the newly formulated electron dispersion laws will introduce new physical ideas and experimental findings under different external conditions. It has been found, taking ultrathin films of n-InAs, n-InSb, n-Hg1-xCdxTe,n-In1-xGaxAsyP1-y lattice matched to InP, as examples, that the respective DMR in the aforementioned materials exhibits decreasing quantum step dependence with the increasing film thickness, decreasing electron statistics, increasing light intensity and wavelength, with different numerical values. The DMR decreases with increasing alloy composition and the nature of the variations are totally band structure dependent which is influenced by the presence of the different energy band constants. The strong dependence of the DMR on both the light intensity and the wavelength reflects the direct signature of the light waves which is in contrast as compared with the corresponding ultrathin films of the said materials in the absence of photo-excitation. The well-known result for the DMR for degenerate wide gap materials in the absence of any field has been obtained as a special case of the present analysis under certain limiting conditions and this compatibility is the indirect test of our generalized formalism. Besides, we have suggested an experimental method of determining the DMR in ultrathin materials in the presence of light waves having arbitrary dispersion laws.

Superhydrophobic surfaces review: Functional application, fabrication techniques and limitations:

Abstract: Over the years, researchers have been working to mimic the nature by inducing superhydrophobic properties into a variety of material surfaces so that they exhibit non-wetting properties. Ma...

Fluoride concentration in ground water and prevalence of dental fluorosis in Ethiopian Rift Valley: systematic review and meta-analysis.

Abstract: The concentration of fluoride in ground drinking water greater than the world health organization standard value imposes a serious health, social and economic problem in developing countries. In the Ethiopian Rift Valley where deep wells are the major source of drinking water, high fluoride level is expected. Though many epidemiological studies on fluoride concentration and its adverse effects have been conducted in the region, the result is highly scattered and needs systematically summarized for better utilization. This research is aimed at estimating the pooled level of fluoride concentration in ground drinking water and the prevalence of dental fluorosis among Ethiopian rift valley residences. Cochrane library, MEDLINE/PubMed and Google scholar databases were searched for studies reporting the mean concentration of fluoride in ground water and prevalence of dental fluorosis in Ethiopian Rift valley. Search terms were identified by extracting key terms from reviews and selected relevant papers and review medical subject headings for relevant terms. The mean fluoride level in ground water and the prevalence of dental fluorosis were pooled from eleven and nine primary studies conducted in Ethiopian Rift Valley respectively. The pooled mean level of fluoride in ground water therefore was 6.03 mg/l (95% CI; 4.72–7.72, p < 0.001) and the pooled prevalence of dental fluorosis among residents in Ethiopian rift valley was 32% (95% CI: 25, 39%, p < 0.001), 29% (95% CI: 22, 36%, p < 0.001) and 24% (95% CI: 17, 32%, p < 0.001 for mild, moderate and sever dental fluorosis respectively. The overall prevalence of dental fluorosis is 28% (95% CI, 24, 32%, p < 0.001). Though, the concentration level varies across different part of the rift valley region, still the level of fluoride in ground drinking water is greater than the WHO standard value (1.5 mg/l). Relatively high-level pooled prevalence of dental fluorosis was also seen in Ethiopian rift valley. Therefore, further studies covering the temperature, exposure time and other intake path ways with large sample size is recommended. Interventional projects should be implemented to decrease the concentration of fluoride in the ground drinking water source.