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A. Dutton

Bio: A. Dutton is an academic researcher. The author has contributed to research in topics: Vasopressin & Supraoptic nucleus. The author has an hindex of 1, co-authored 1 publications receiving 340 citations.

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TL;DR: Isolated rat neural lobes were incubated in vitro and electrically stimulated to release vasopressin and there was a reasonably good correlation between results obtained with this assay and those obtained by bioassay with the rat blood pressure method.
Abstract: 1. Isolated rat neural lobes were incubated in vitro and electrically stimulated to release vasopressin. The released vasopressin was assayed using a radioimmunoassay and there was a reasonably good correlation (r = 0.81) between results obtained with this assay and those obtained by bioassay with the rat blood pressure method. 2. Regular stimulation at frequencies of 5, 10 and 20 Hz released progressively more vasopressin and the release could be blocked by addition of tetrodotoxin to the incubation medium. 3. Stimulation with pulse patterns derived from tape recordings of phasically firing units in the supraoptic nucleus of dehydrated rats released more vasopressin than the same number of pulses regularly spaced in time. In the range 2-8 pulses/sec vasopressin release was related to the pulse frequency within the bursts (r = 0.90) and the number of short (< 100 msec) interpulse intervals (r = 0.92). Vasopressin released per pulse increased over the frequency range 3-6 pulses/sec, but above 6 pulses/sec vasopressin release per pulse tended to diminish. 4. We conclude that phasic firing of vasopressin neurosecretory cells may enhance vasopressin release in vivo and that an important factor in determining release is the number of short interspike intervals.

346 citations


Cited by
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Journal ArticleDOI
TL;DR: It is suggested that dysregulation of locus coeruleus-noradrenergic neurotransmission may contribute to cognitive and/or arousal dysfunction associated with a variety of psychiatric disorders, including attention-deficit hyperactivity disorder, sleep and arousal disorders, as well as certain affective Disorders, including post-traumatic stress disorder.

2,207 citations

Journal ArticleDOI
TL;DR: The hypothesis that nerve cells are true secreting cells, and act upon one other and upon the cells of other organs by the passage of a chemical substance of the nature of a ferment or proferment from the first cell to the second is formed.

806 citations

Journal ArticleDOI
TL;DR: In conditions which mimicked the spontaneous activity of dopaminergic neurons when they switch from one pattern to the other, the bursting stimulations were found to be up to 6 times more potent than regularly spaced stimulation, suggesting bursting might be much more important than mean firing frequency as regards the functional efficacy of DA neurons.

694 citations

Journal ArticleDOI
TL;DR: Since BDNF has been proposed to play a critical role as an intercellular synaptic messenger in long-term potentiation (LTP) in the hippocampus, this article tries to reconcile this possible role of BDNF in LTP with the recently described features of synaptic BDNF secretion.

665 citations

Journal ArticleDOI
04 Oct 2012-Neuron
TL;DR: In this article, the authors review converging data revealing a complex interaction between slow-acting neuromodulator peptides and fast-acting amino acid transmitters in the control of energy homeostasis, drug addiction, mood and motivation, sleep-wake states, and neuroendocrine regulation.

557 citations