A
A. Gardet
Researcher at Broad Institute
Publications - 1
Citations - 2504
A. Gardet is an academic researcher from Broad Institute. The author has contributed to research in topics: Downregulation and upregulation & Innate immune system. The author has an hindex of 1, co-authored 1 publications receiving 1902 citations.
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.