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A. Haemers
Researcher at University of Antwerp
Publications - 20
Citations - 555
A. Haemers is an academic researcher from University of Antwerp. The author has contributed to research in topics: Diaminopimelic acid & Ames test. The author has an hindex of 8, co-authored 20 publications receiving 538 citations. Previous affiliations of A. Haemers include National Health Research Institutes.
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Journal ArticleDOI
4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.
N. De Meyer,A. Haemers,Lallan Mishra,H. K. Pandey,Luc Pieters,D. Vanden Berghe,A. J. Vlietinck +6 more
TL;DR: The most interesting compound was 4',7-dihydroxy-3-methoxy-5,6-dimethylflavone possessing in vitro TI99 values of greater than 1000 and greater than 200 against poliovirus type 1 and rhinovirus type 15, respectively, and showed to be not mutagenic in concentrations up to 2.5 mg in the Ames test.
Journal Article
The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors.
Koen Augustyns,Gunther Bal,G. Thonus,A. Belyaev,X. M. Zhang,W. Bollaert,Anne-Marie Lambeir,Christine Durinx,Filip Goossens,A. Haemers +9 more
TL;DR: In this paper, the properties and functions of dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5) were discussed, and the role of CD26 in the intestinal and renal handling of proline containing peptides, in cell adhesion, in peptide metabolism, in the immune system and in HIV infection.
Journal ArticleDOI
The Unique Properties of Dipeptidyl-Peptidase IV (DPP IV / CD26) and the Therapeutic Potential of DPP IV Inhibitors
Koen Augustyns,Gunther Bal,G. Thonus,A. Belyaev,X. M. Zhang,W. Bollaert,Anne-Marie Lambeir,Christine Durinx,Filip Goossens,A. Haemers +9 more
TL;DR: The latest developments in the search for new inhibitors will be reported as well as the discovery of new natural substrates for DPP IV such as the glucagon-like peptides and the chemokines.
Journal ArticleDOI
Irreversible Inhibition of Dipeptidyl Peptidase 8 by Dipeptide-Derived Diaryl Phosphonates
Pieter Van der Veken,Anna Soroka,Inger Brandt,Yuan-Shou Chen,Marie-Berthe Maes,Anne-Marie Lambeir,Xin Chen,A. Haemers,Simon Scharpé,Koen Augustyns,Ingrid De Meester +10 more
TL;DR: Dipeptide-derived compounds, bearing various P2 residues and a diaryl pyrrolidin-2-yl phosphonate at the P1 position, were evaluated as dipeptidyl peptidase 8 (DPP8) inhibitors and compound 2e was shown to be a potent, irreversible inhibitor of DPP8, demonstrating very low affinity for DPP IV and DPP II.
Journal ArticleDOI
Synthesis and antibacterial evaluation of phosphonic acid analogues of diaminopimelic acid
TL;DR: In this paper, the synthesis of a series of phosphonic acid analogues of this diamino-dicarboxylic acid is described: mono- and diphosphonic acid derivatives as well as their homologues, N -alkyl analogues and some peptidyl derivatives.