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A. Hofmann

Bio: A. Hofmann is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 10 citations.

Papers
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Journal ArticleDOI
TL;DR: In this paper, die Isolierung von β-Yohimbin aus den Wurzeln von Rauwolfia canescens L. beschrieben.
Abstract: Es wird die Isolierung von β-Yohimbin aus den Wurzeln von Rauwolfia canescens L. beschrieben.

10 citations


Cited by
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Journal ArticleDOI
TL;DR: Aus den schwach basischen Gesamtalkaloiden der Wurzelrinde von Diplorrhynchus condylocarfion(MUELL ARG) PICHONssp mossambicensis(BENTH) DUVIGN wurden 7 Alkaloide isoliert, die zwei Strukturtypen angehoren
Abstract: Aus den schwach basischen Gesamtalkaloiden der Wurzelrinde von Diplorrhynchus condylocarfion(MUELL ARG) PICHONssp mossambicensis(BENTH) DUVIGN wurden 7 Alkaloide isoliert, die zwei Strukturtypen angehoren

49 citations

Journal ArticleDOI
TL;DR: In this paper, die Dieckmann-Ringschlus des leicht herstellbaren Diesters 4a gelingt ein einfacher Aufbau des Yohimban-Gerustes mit guter Ausbeute.
Abstract: Mit dem Dieckmann-Ringschlus des leicht herstellbaren Diesters 4a gelingt ein einfacher Aufbau des Yohimban-Gerustes mit guter Ausbeute. Durch Reduktion des Yohimbinons (6b) sowie durch Hydrolyse der Saureamide 7c und 8c wurden das (±)-Yohimbin (7a) und das (±)-β-Yohimbin (8a) synthetisiert. Die racem. Produkte liesen sich mit N-Acetyl-L-leucin bzw. L-Camphersulfonsaure spalten.

27 citations

Journal ArticleDOI
TL;DR: Aufgrund von Substitutions-, Reduktions-and Oxydationsversuchen wird fur das Rauwolfia-Alkaloid Sarpagin eine Strukturformel vorgeschlagen, welche mit den in dieser Alkaloidsgruppe entwickelten biogenetischen Vorstellungen im Einklang steht as mentioned in this paper.
Abstract: Auf Grund von Substitutions-, Reduktions- und Oxydationsversuchen wird fur das Rauwolfia-Alkaloid Sarpagin eine Strukturformel vorgeschlagen, welche mit den in dieser Alkaloidgruppe entwickelten biogenetischen Vorstellungen im Einklang steht.

12 citations

Journal ArticleDOI
TL;DR: Although rauwolfia may ultimately not survive to take its place alongside the solanaceous drugs, the cardiac glycosides and opium, a study of its properties seems likely to lead to a clearer understanding of the complex mechanism underlying hypertensive disease in man.
Abstract: OVER the past two or three decades much attention has been paid by clinicians to the treatment of hypertensive disease. This has resulted in the introduction and trial of a number of drugs, including, amongst others, thiocyanates, nitroprussides, azides, hydrazinophthalazine (hydrallazine), veratrum, the ganglion blocking agents, ion exchange resins, barbiturates and the various extracts and alkaloids of Rauwolfia serpentina Benth. The introduction and use of Rauwolfia serpentina is of particular interest ; not only has it intriguing pharmacological properties, but it represents something of a return to the use of vegetable drugs, in an age which is becoming increasingly devoted to the use of synthetic chemicals in medicine. Although rauwolfia may ultimately not survive to take its place alongside the solanaceous drugs, the cardiac glycosides and opium, a study of its properties seems likely to lead to a clearer understanding of the complex mechanism underlying hypertensive disease in man. In this way it may establish itself firmly in the history of medicine. This may seem to be a jaundiced view to take of a new drug which is being widely used and widely studied. Many natural products have proved to be the starting points for further investigation and have yielded place to newer drugs with structures based upon the originals. A study of the literature indicates that this may be the fate of rauwolfia.

12 citations

Book ChapterDOI
01 Jan 1965
TL;DR: This chapter describes Rauwolfia alkaloids with special reference to the chemistry of reserpine, which has become important therapeutic agents, both as sedatives and antihypertensives.
Abstract: Publisher Summary This chapter describes Rauwolfia alkaloids with special reference to the chemistry of reserpine. Rauwolfia products have become important therapeutic agents, both as sedatives and antihypertensives. Although their production and use have fallen off since the peak years of 1955 and 1956, it is estimated that their total sales a t the consumers' level in 1961 still amounted to $100 million in the United States alone. Since 1952, the year reserpine was first isolated, several thousand articles have been published on the isolation, chemistry, pharmacology, and clinical aspects of reserpine and other Rauwolfia alkaloids, and today these investigations are still being pursued. Botanists estimate the number of identified Rauwolfia species to be about 50, of which R. serpentina, R. canescens, R. vomitoria, and R. ligustrina have been investigated in detail. Only the first three species are important from the standpoint of supplies of therapeutically useful alkaloids; the last species is not especially rich in reserpine, but has nevertheless been investigated in great detail. The Indian plant, R. serpentina, has lost much of its importance (except for local production), as its reserpine content (0.1%) is only about half that of R. vomitoria, which is at present the most important species. It grows so plentifully in Central Africa, especially in the Congo, that cultivation is not necessary. It is considerably taller than R. serpentina, and procedures have been developed by Congolese collectors by which the smaller side roots may be cut periodically without loss of the tree.

11 citations