Author
A.J. Chacko
Bio: A.J. Chacko is an academic researcher from Mahatma Gandhi University. The author has contributed to research in topics: Chitosan & Controlled release. The author has an hindex of 9, co-authored 10 publications receiving 625 citations.
Papers
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TL;DR: From the intestinal lymphatic transport study it became evident that SLN increased the cumulative percentage dose of lopinavir secreted into the lymph, which was 4.91-fold higher when compared with a conventional drug solution in methyl cellulose 0.5% (w/v) as suspending agent (Lo-MC).
212 citations
TL;DR: In vivo studies revealed a significant reduction in blood glucose level after administration of the optimized formulation, in comparison to a subcutaneous insulin injection, and chitosan microspheres were superior in terms of sustaining protein release over conventional insulin therapy.
86 citations
TL;DR: Insulin-loaded chitosan microspheres for oral delivery showed to be an innovative and reliable delivery system to overcome conventional insulin therapy and a non-Fickian diffusion as the mechanism of insulin release.
86 citations
Journal Article•
TL;DR: In this article, diltiazem hydrochloride (DTZ) was encapsulated in the microspheres, following Eudragit S-100 coating by solvent evaporation technique, exploiting the advantages of microbiological properties of chitosan and pH dependent solubility of S100.
63 citations
TL;DR: Chitosan biodegradability was proven by the enhanced release rate of DTZ in presence of rat caecal contents, and thus suitable for colon-specific drug delivery.
62 citations
Cited by
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TL;DR: It is found that the use of chitosan nanoparticles greatly increases the transport of drugs from nose to brain over and above the effect of simpler chitOSan formulations.
331 citations
TL;DR: This review gives an overview of relevant properties of alginate as oral colon delivery systems and the recent innovative strategies of usingAlginate with other polymers as well as microencapsulation techniques and describes the several advantages of coating processes involving alginates over microparticles in order to design better material with sustained release characteristic for colon-targeted delivery.
294 citations
TL;DR: N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.
286 citations
TL;DR: Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics.
Abstract: Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment. Toxicity often limits the usefulness of anticancer agents being also the reason why many patients discontinue the treatment. The nutritional approach may be the means of helping to raise cancer therapy to a new level of success as supplementing or supporting the body with natural phytochemicals cannot only reduce adverse side effects but improve also the effectiveness of chemotherapeutics. Various plant-derived compounds improve the efficiency of cytotoxic agents, decrease their resistance, lower and alleviate toxic side effects, reduce the risk of tumour lysis syndrome, and detoxify the body of chemotherapeutics. The personalised approach using various phytochemicals provides thus a new dimension to the standard cancer therapy for improving its outcome in a complex and complementary way.
270 citations
TL;DR: This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as effective nanocolloidal system for drug delivery and summarizes SLNs in terms of their preparation, surface modification and properties.
250 citations