Author
A.J.H. Van Es
Bio: A.J.H. Van Es is an academic researcher. The author has contributed to research in topics: Reference Daily Intake. The author has an hindex of 3, co-authored 4 publications receiving 1928 citations.
Topics: Reference Daily Intake
Papers
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1,931 citations
14 citations
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TL;DR: It was concluded that optimum bacterial growth in the rumen occurs when EMPS is 29 g of bacterial N/kg of fermented organic matter, and ENU is 69%, implying that bacteria would require about 1.31 x rumen-available N per unit ofacterial N.
1,144 citations
TL;DR: A review of factors influencing heat stress in lactating dairy cows and how it affects milk production is provided in this article, where the thermoneutral zone, heat production and heat gain, heat dissipation mechanisms, and how the lactating cow responds to heat stress are discussed.
1,100 citations
01 Jan 1995
TL;DR: This work has shown that purine metabolism in ruminants is regulated by a mixture of xanthine plus hypoxanthine and uric acid, and the determination of allantoin by a colorimetric method and that the latter is determined by an enzymatic method.
Abstract: Introduction 1 Principle of the method 1 Brief background of purine metabolism in ruminants 2 Limitation of the method 5 Sample collection 5 Determination of purine derivatives 6 Dilution of urine samples 6 List of published methods 8 Determination of allantoin by a colorimetric method 9 Determination of xanthine plus hypoxanthine by enzymatic method 12 Determination of uric acid by uricase method 15 Calculations 16 Daily excretion of purine derivatives 17 Calculation of microbial N supply 17 Presentation of results 18 Use of spot samples 19 Related Literature 19
1,060 citations
TL;DR: The data provide the first evidence that clinically relevant reductions in specific dietary inputs to the methionine/folate cycles during the periconceptional period can lead to widespread epigenetic alterations to DNA methylation in offspring, and modify adult health-related phenotypes.
Abstract: A complex combination of adult health-related disorders can originate from developmental events that occur in utero. The periconceptional period may also be programmable. We report on the effects of restricting the supply of specific B vitamins (i.e., B12 and folate) and methionine, within normal physiological ranges, from the periconceptional diet of mature female sheep. We hypothesized this would lead to epigenetic modifications to DNA methylation in the preovulatory oocyte and/or preimplantation embryo, with long-term health implications for offspring. DNA methylation is a key epigenetic contributor to maintenance of gene silencing that relies on a dietary supply of methyl groups. We observed no effects on pregnancy establishment or birth weight, but this modest early dietary intervention led to adult offspring that were both heavier and fatter, elicited altered immune responses to antigenic challenge, were insulin-resistant, and had elevated blood pressure–effects that were most obvious in males. The altered methylation status of 4% of 1,400 CpG islands examined by restriction landmark genome scanning in the fetal liver revealed compelling evidence of a widespread epigenetic mechanism associated with this nutritionally programmed effect. Intriguingly, more than half of the affected loci were specific to males. The data provide the first evidence that clinically relevant reductions in specific dietary inputs to the methionine/folate cycles during the periconceptional period can lead to widespread epigenetic alterations to DNA methylation in offspring, and modify adult health-related phenotypes.
745 citations
TL;DR: In early lactation, dietary CP and energy can profoundly affect milk yield, but current methods of assessing these nutrients are often inadequate to predict animal performance.
628 citations