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A. K. Smailov

Bio: A. K. Smailov is an academic researcher. The author has co-authored 1 publications.
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Journal Article•DOI•
New intramolecular cyclization of 2H-benzo[e]-1,2-oxaphosphorinine derivatives—a way to the synthesis of unsymmetrical cage phosphonates

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Alena V. Zalaltdinova1, Yu. M. Sadykova1, A. K. Smailov, Larisa M. Trofimova2, A. R. Burilov1, Michael A. Pudovik1 •
Kazan Federal University1, Chuvash State University2
29 Nov 2021-Phosphorus Sulfur and Silicon and The Related Elements

1 citations

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Journal Article•DOI•
Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity

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Valeriia V. Sennikova, Alena V. Zalaltdinova, Yulia M. Sadykova, Ayrat R. Khamatgalimov, Almir S. Gazizov, Alexandra D. Voloshina, Anna P. Lyubina, Syumbelya K. Amerhanova, Julia K. Voronina, Elena Chugunova, N. O. Appazov, Alexander R. Burilov, M. A. Pudovik 
01 Nov 2022-International Journal of Molecular Sciences
TL;DR: In this paper , a regio-and diastereoselective synthesis of pyrrolidine-fused spiro-dihydrophosphacoumarins via intermolecular cycloaddition reaction is presented.
Abstract: Herein we present the regio- and diastereoselective synthesis of novel pyrrolidine-fused spiro-dihydrophosphacoumarins via intermolecular [3 + 2] cycloaddition reaction. The presented approach is complementary to existing ones and provides an easy entry to the otherwise inaccessible derivatives. Additionally, the unprecedented pathway of the reaction of 4-hydroxycoumarin with azomethine ylides is described. The anti-cancer activity of the obtained compounds was tested in vitro, the most potent compound being 2.6-fold more active against the HuTu 80 cell line than the reference 5-fluorouracil, with a selectivity index > 32.

2 citations