scispace - formally typeset
Search or ask a question
Author

A. Lecci

Bio: A. Lecci is an academic researcher. The author has contributed to research in topics: Desipramine & Lactam. The author has an hindex of 6, co-authored 10 publications receiving 139 citations.

Papers
More filters
Journal ArticleDOI
TL;DR: Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione, and TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/ kg did not modify the pattern ofSIH at all.
Abstract: 8-OH-DPAT (2.5–10 mg/kg) and buspirone (10 mg/kg) but not 5,7DHT (200 Μg/mouse), pCPA (75 and 150 mg/kg, three times), ritanserin (0.1 and 0.2 mg/kg), LY 53857 (1.5 and 3 mg/kg), GR 38032 F (0.1–100 Μg/kg), TFMPP (5 and 20 mg/kg) and mCPP (2.5 and 5 mg/kg) antagonized the rise in body temperature that occurs to the last mice removed from their group housing, which was termed as stress-induced hyperthermia (SIH). Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione. Instead, when cerebral 5-HT content was reduced to 50% by 5,7-DHT-induced lesion, the effect of buspirone on SIH was decreased. TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/kg did not modify the pattern of SIH at all. The lower dose of TFMPP evoked a hyperthermic and the higher a hypothermic response.

54 citations

Journal ArticleDOI
TL;DR: A new series of 11-[(aminoalkyl)carbonyl] derivatives of 6,11-dihydrodibenzo[c,f][1,2,5]thiadiazepine 5,5-dioxide (10-39) were synthesized and evaluated for potential antidepressant activity in the apomorphine-induced hypothermia (Apo 16) test.
Abstract: A new series of 11-[(aminoalkyl) carbonyl] derivatives of 6,11-dihydrobibenzo [c,f] [1,2,5] thiadiazepine 5,5-dioxide (10-39) were synthesized and evaluated for potential antidepressant activity in the apomorphine-induced hypothermia (Apo 16) tests. Effects on reserpine-induced hypothermia and toxicity for the most potent antagonists of Apo 16 hypothermia were also studied. Structure-activity relationships are reported. Anticholinergic effects were evaluated for compound 12, identified as the most potent and least toxic in this series, by assessing physostigmine lethality. Compound 12 was also subjected to X-ray analysis

39 citations

Journal ArticleDOI
TL;DR: Stress-induced hyperthermia (SIH), which is seen in the last mice removed from the cage, is a novel animal model sensitive to anxiolytic drugs and MK-801 (0.5–1 mg/kg, os), PCP, PCP and d-amphetamine evokedhyperthermia in the first set of mice and prevented a further stress-induced rise of body temperature in theLast set of mouse.
Abstract: Stress-induced hyperthermia (SIH), which is seen in the last mice removed from the cage, is a novel animal model sensitive to anxiolytic drugs. SIH is antagonized by CL 218872 (25 and 50 mg/kg, os), by tracazolate (5 and 7.5 mg/kg, ip) and by 2-AP-5 (50 and 100 mg/kg, ip). At higher dose, CL 218872 (100 mg/kg, os) and tracazolate (12.5 mg/kg, ip) lose their activity.

17 citations

Journal ArticleDOI
TL;DR: Nomifensine induced an anti-immobility effect that was maximal during the light phase of the light/dark cycle and was constant in continuous darkness.
Abstract: In order to verify whether the variability reported to occur in the effectiveness of antidepressants in the forced swimming test (FST) was due to seasonal and/or circadian variations, the anti-immobility effect induced by several antidepressants was assessed in rats every month throughout the year or every 4 hours for 2 consecutive days. Amineptine (20 mg/kg), amitriptyline (15 mg/kg), desipramine (20 mg/kg), imipramine (15 mg/kg) and mianserin (15 mg/kg) exerted the maximal effect in March. The effect of nomifensine (5 mg/kg) was constant throughout the year. Unlike imipramine and mianserin, nomifensine induced an anti-immobility effect that was maximal during the light phase of the light/dark cycle and was constant in continuous darkness.

10 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: It is suggested that the commonly used experimental one-day methamphetamine dosing regimen better models the acute overdose pathologies seen in humans, whereas chronic models are needed to accurately model human long-term abuse.

496 citations

Journal ArticleDOI
TL;DR: Observations lead to the conclusion that different 5-HT mechanisms, mediated by different receptor subtypes, are involved in the genesis of anxiety.

448 citations

Journal ArticleDOI
TL;DR: The previously published literature is analyzed for factors which are known to influence animal behavior in the FST, and consideration of these factors in planning experiments may result in more consistent FST results.

318 citations

Journal ArticleDOI
TL;DR: Neurons concentrated in the dorsal region of the DMH project directly to the rRP, a location corresponding to that of neurons trans-synaptically labeled from IBAT, and these neurons control nonshivering thermogenesis in rats, and their activation signals its recruitment in diverse experimental paradigms.
Abstract: Neurons in the dorsomedial hypothalamus (DMH) play key roles in physiological responses to exteroceptive (“emotional”) stress in rats, including tachycardia. Tachycardia evoked from the DMH or seen...

293 citations