A. Manoharan

TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.

TL;DR: Genome-wide analysis of the nematode worm indicates a role for complex expression of 3′ untranslated regions in development, and identifies conserved 3′UTR motifs, isoform-specific predicted microRNA target sites, and polyadenylation of most histone genes.

TL;DR: Two nonoverlapping subclasses of 26G RNAs are identified that sort into specific RNA-induced silencing complexes (RISCs) and differentially regulate distinct mRNA targets and implicate a class of endo-siRNAs in the global regulation of transcriptional programs required for fertility and development.

TL;DR: Differentially expressed proteins differentially expressed in six Barrett metaplasia samples may have utility as useful candidate markers of esophageal adenocarcinoma.

TL;DR: The analysis highlights the unreliability of ethnicity classification based on patient self-reports and recommends the routine use of pan-ethnic carrier screening panels in reproductive medicine and the use of an ancestry model would allow better estimation of carrier rates and residual risks.