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A Manolis

Bio: A Manolis is an academic researcher. The author has contributed to research in topics: Environmental exposure & Breath gas analysis. The author has an hindex of 1, co-authored 1 publications receiving 400 citations.

Papers
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413 citations


Cited by
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Journal ArticleDOI
TL;DR: In this paper, a proton transfer reaction mass spectrometer (PTR-MS) was developed which allows for on-line measurements of trace components with concentrations as low as a few pptv.

1,542 citations

Journal ArticleDOI
TL;DR: This research presents a meta-analysis of 126 existing and new technologies in the gas chromatography field, and some new technologies that are being developed, as well as suggestions for further studies.
Abstract: 2.2. New Approaches 707 2.2.1. Optical Sensor Systems 707 2.2.2. Mass Spectrometry 708 2.2.3. Ion Mobility Spectrometry 708 2.2.4. Gas Chromatography 709 2.2.5. Infrared Spectroscopy 709 2.2.6. Use of Substance-Class-Specific Sensors 709 2.3. Combined Technologies 710 3. Companies 710 4. Application Areas 710 4.1. Food and Beverage 712 4.2. Environmental Monitoring 715 4.3. Disease Diagnosis 716 5. Research and Development Trends 718 5.1. Sample Handling 719 5.2. Filters and Analyte Gas Separation 719 5.3. Data Evaluation 720 6. Conclusion 721 7. References 722

1,266 citations

Journal ArticleDOI
29 Jun 2009-Sensors
TL;DR: This paper is a review of the major electronic-nose technologies developed since this specialized field was born and became prominent in the mid 1980s, and a summarization of some of the more important and useful applications that have been of greatest benefit to man.
Abstract: Electronic-nose devices have received considerable attention in the field of sensor technology during the past twenty years, largely due to the discovery of numerous applications derived from research in diverse fields of applied sciences. Recent applications of electronic nose technologies have come through advances in sensor design, material improvements, software innovations and progress in microcircuitry design and systems integration. The invention of many new e-nose sensor types and arrays, based on different detection principles and mechanisms, is closely correlated with the expansion of new applications. Electronic noses have provided a plethora of benefits to a variety of commercial industries, including the agricultural, biomedical, cosmetics, environmental, food, manufacturing, military, pharmaceutical, regulatory, and various scientific research fields. Advances have improved product attributes, uniformity, and consistency as a result of increases in quality control capabilities afforded by electronic-nose monitoring of all phases of industrial manufacturing processes. This paper is a review of the major electronic-nose technologies, developed since this specialized field was born and became prominent in the mid 1980s, and a summarization of some of the more important and useful applications that have been of greatest benefit to man.

887 citations

Journal ArticleDOI
TL;DR: In this paper, the basic principles of breath analysis and the diagnostic potential of different volatile breath markers are discussed, along with analytical procedures, issues concerning biochemistry and exhalation mechanisms of volatile substances, and future developments.

852 citations

Journal ArticleDOI
TL;DR: A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported and it is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of V OCs from healthy individuals.
Abstract: A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urine (279), and faeces (381) in apparently healthy individuals. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been grouped into tables according to their chemical class or functionality to permit easy comparison. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces. Careful use of the database is needed. The numbers may not be a true reflection of the actual VOCs present from each bodily excretion. The lack of a compound could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from blood compared to a large number on VOCs in breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. collecting excretions on glass beads and then heating to desorb VOCs. All compounds have been included as reported (unless there was a clear discrepancy between name and chemical structure), but there may be some mistaken assignations arising from the original publications, particularly for isomers. It is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of VOCs from healthy individuals. Establishing a list of volatiles emanating from healthy individuals and increased understanding of VOC metabolic pathways is an important step for differentiating between diseases using VOCs.

764 citations