A. Mas

Bio: A. Mas is an academic researcher from University of Liverpool. The author has contributed to research in topics: Exocrine pancreatic insufficiency & Angiostrongylus vasorum. The author has an hindex of 5, co-authored 8 publications receiving 128 citations.

Emerging canine angiostrongylosis in northern England: five fatal cases.

Abstract: Angiostrongylus vasorum is a metastrongylid nematode parasite that resides in the pulmonary arteries and right ventricle of dogs and other canids Since its discovery in France in 1866 by Baillet ([Rosen and others 1970][1]), A vasorum has been reported in dogs in Europe (Denmark, France, Germany,

Canine tonsillar squamous cell carcinoma – a multi-centre retrospective review of 44 clinical cases

Abstract: Objectives: To review the presenting clinical signs, treatment and survival of dogs with tonsillar squamous cell carcinoma and, if possible, to identify useful prognostic indicators. Methods: Medical records of 44 dogs were reviewed retrospectively. Clinical signs, clinical stage, time of diagnosis, treatment and outcome were recorded. Data were analysed using the Kaplan-Meier, log-rank, Student's t test, Kruskal-Wallis test and Chi-square/Fisher Exact test as appropriate. Results: The most frequent clinical signs were cough (12 dogs, 27%), enlarged lymph nodes (11 dogs, 25%) and dysphagia (11 dogs, 25%). Anorexia and lethargy were less common but were significantly associated with a poor outcome. No matter what treatment modalities were used, survival times were short and median survival time for all the dogs in the study was 179 days. However, there were a small number of long-term survivors. Clinical Significance: Dogs with tonsillar squamous cell carcinoma that suffered anorexia and lethargy had shorter survival times than patients without these clinical signs. Although surgery, chemotherapy and radiotherapy seem to increase the median survival time of dogs diagnosed with tonsillar squamous cell carcinoma, there is no highly effective treatment for canine tonsillar squamous cell carcinoma.

Emerging canine angiostrongylosis in northern England: five fatal cases

Abstract: Angiostrongylus vasorum is a metastrongylid nematode parasite that resides in the pulmonary arteries and right ventricle of dogs and other canids. Since its discovery in France in 1866 by Baillet (Rosen and others 1970), A vasorum has been reported in dogs in Europe (Denmark, France, Germany, Ireland, Italy, Spain, Sweden, Switzerland, Turkey and the UK), Africa (Uganda), South America (Brazil and Columbia) and Canada (Newfoundland) (Brennan and others 2004, Bourque and others 2008, Traversa and Guglielmini 2008). It is widely assumed that foxes act as a reservoir of infection for dogs and a recent study has shown that infection is endemic in foxes in areas of the UK where there is a high incidence of A vasorum infection in canines (Morgan and others 2008). In the UK, canine A vasorum infection was first reported in Cornwall in 1982 (Simpson and Neal 1982) with further cases appearing in South Wales in 1987 (Patteson and others 1987, Trees 1987). In the past decade, the disease has been increasingly diagnosed in dogs in the south east of England (Chapman and others 2004) and recently an autochthonous case was reported in Glasgow (J. Dukes-McEwan, personal communication). There have so far been no published cases of canine A vasorum infection in northern England, and infection has been absent in foxes (Morgan and others 2008). Although clinical signs in association with A vasorum infection in dogs can be variable, they typically represent three main syndromes: cardiorespiratory signs, coagulopathies and neurological dysfunction (Koch and Willesen 2008). Dogs with cardiorespiratory signs present with a history that may include chronic coughing, exercise intolerance, syncope, dyspnoea and tachypnoea (Bolt and others 1994), whereas the coagulopathies can result in anaemia, subcutaneous haematomas, internal haemorrhages and prolonged bleeding from wounds or after surgery (Ramsey and others 1996, …

The effect of boric acid on bacterial culture of canine and feline urine.

Abstract: Objective: To identify the optimal method of submission of canine and feline urine for bacterial culture. Methods: Cystocentesis samples from 250 animals (200 dogs, 50 cats) suspected of having urinary tract infections were collected. The reference aliquot, without preservative, was processed on site within 2 hours. Two further aliquots (one without preservative, one with boric acid) were stored at room temperature for up to 7 hours and then posted by guaranteed next day delivery to a commercial laboratory for analysis. Results: Forty-seven of the samples were positive on culture in the reference test. There was no significant difference between reference test results and those of samples posted without preservative (P=0·39), but samples posted in boric acid were significantly less likely to give a positive result (P=0·01). Samples posted without preservative had a sensitivity of 82% and a specificity of 98%; for boric acid, sensitivity was 73% and specificity 99%. Clinical Significance: Postal urine samples should be submitted to the laboratory in a plain sterile tube.

Clinical leishmaniasis in dogs living in the UK

Abstract: OBJECTIVES To investigate the prevalence of leishmaniasis in dogs in the UK and to describe clinical presentation, clinicopathological abnormalities, therapeutic protocols and outcome in this non-endemic country. MATERIALS AND METHODS Medical records of dogs diagnosed with leishmaniasis at seven referral centres in the UK were retrospectively reviewed. RESULTS The prevalence was between 0·007 and 0·04% with a higher number of cases in southern England. All dogs had a history of travel to or from an endemic country. Lethargy, dermatological disease, decreased appetite and lameness were the most common reasons for presentation. Allopurinol was used alone for treatment in the majority of cases. CLINICAL SIGNIFICANCE Although rare, leishmaniasis should be considered in dogs in the UK if they have compatible clinical signs and history of travel to or from endemic areas.

Canine and feline cardiopulmonary parasitic nematodes in Europe: emerging and underestimated

Abstract: Cardiopulmonary nematodes of dogs and cats cause parasitic diseases of central relevance in current veterinary practice. In the recent past the distribution of canine and feline heartworms and lungworms has increased in various geographical areas, including Europe. This is true especially for the metastrongyloids Aelurostrongylus abstrusus, Angiostrongylus vasorum and Crenosoma vulpis, the filarioid Dirofilaria immitis and the trichuroid Eucoleus aerophilus (syn. Capillaria aerophila). The reasons of this emergence are little known but many drivers such as global warming, changes in vector epidemiology and movements in animal populations, may be taken into account. The purpose of this article is to review the knowledge of the most important heartworm and lungworm infections of dogs and cats in Europe. In particular recent advances in epidemiology, clinical and control are described and discussed.

Canine angiostrongylosis: an emerging disease in Europe

Abstract: Objective – The aim of this article is to review Angiostrongylus vasorum infection in dogs, including the life cycle, signalment, clinical signs, diagnosis, and treatment. Apparent changes in the epidemiology of this unique parasite are considered, alongside information available regarding its recent geographic spread. Etiology – A. vasorum is a metastrongyloid parasite capable of causing an array of clinical problems in dogs, including cardiorespiratory, coagulopathic, and neurologic signs. Currently, the parasite has a worldwide distribution; however, it usually arises in small pockets of enzootic foci. Recent reports suggest a changing distribution of this parasite, which has renewed interest in its epidemiology and in the risk of expansion to new areas including mainland North America. Diagnosis – A definitive diagnosis of angiostrongylosis is usually made using the modified Baermann technique either using feces or tracheobronchial secretions; however, this review also discusses novel methods such as serologic and molecular techniques. Therapy – Once a diagnosis of angiostrongylosis is made, prompt treatment should follow with anthelmintic drugs (such as moxidectin/imidacloprid, milbemycin oxime, or fenbendazole) and supportive care dependent upon the patient's clinical signs. Currently, there is no proven prophylactic regime. Prognosis – The prognosis appears to be very dependent upon the severity of clinical signs at presentation. A. vasorum can be fatal and death may be sudden. However, if a prompt diagnosis is made and appropriate treatment is administered complete clinical resolution is possible.

ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease

Abstract: Practical relevance:Chronic kidney disease (CKD) is one of the most commonly diagnosed diseases in older cats. In most cats, CKD is also a progressive disease and can be accompanied by a wide range of clinical and clinicopathological changes. These ISFM Consensus Guidelines have been developed by an independent panel of clinicians and academics to provide practical advice on the diagnosis and management of this complex disease.Clinical challenges:Although CKD is a common clinical problem in cats, the manifestations of disease vary between individuals. Thus there is a need for careful and repeat evaluation of cats with CKD and adjustment of therapy according to individual needs. In addition to addressing problems arising from CKD and improving quality of life (QoL) for the patient, therapy may also target slowing the underlying progression of disease and hence prolonging life. While maintaining QoL is of paramount importance in our patients, this can be challenging when multiple therapies are indicated. In...

Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing.

Abstract: Infectious diseases caused by bacterial pathogens remain one of the most common causes of morbidity and mortality worldwide. Rapid microbiological analysis is required for prompt treatment of bacterial infections and to facilitate antibiotic stewardship. This study reports an adaptable microfluidic system for rapid pathogen classification and antimicrobial susceptibility testing (AST) at the single-cell level. By incorporating tunable microfluidic valves along with real-time optical detection, bacteria can be trapped and classified according to their physical shape and size for pathogen classification. By monitoring their growth in the presence of antibiotics at the single-cell level, antimicrobial susceptibility of the bacteria can be determined in as little as 30 minutes compared with days required for standard procedures. The microfluidic system is able to detect bacterial pathogens in urine, blood cultures, and whole blood and can analyze polymicrobial samples. We pilot a study of 25 clinical urine samples to demonstrate the clinical applicability of the microfluidic system. The platform demonstrated a sensitivity of 100% and specificity of 83.33% for pathogen classification and achieved 100% concordance for AST.