Author
A. Montfoort
Bio: A. Montfoort is an academic researcher from Utrecht University. The author has contributed to research in topics: Lecithin & Phosphatidylcholine. The author has an hindex of 2, co-authored 2 publications receiving 262 citations.
Papers
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TL;DR: The composition of lecithins from lung and brain showed many similarities irrespective of animal species, which may indicate a certain degree of tissue specificity.
142 citations
TL;DR: The results indicate that, in liver, a de novo synthesis is primarily operating in the biosynthesis of linoleic acid-containing molecules of lecithin and of the hexaenoic molecular species of phosphatidylethanolamine and, in lung, an acylation of monoacyl derivatives of these phospholipids is suggested to play an important role particularly in the formation of arachidonic acid containing molecular Species of theseospholipid.
120 citations
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1,590 citations
TL;DR: The period of discovery of new lipids in the nervous system appears to be over and all the major lipid components have been discovered and a great deal is now known about their structure and metabolism.
694 citations
TL;DR: The data indicate that the cytidylytransferase reactions are rate-limiting steps in the synthesis of phosph atidylethanolamine and probably also phosphatidylcholine, and the availability of diacylglycerol and its fatty acid composition may significantly affect the rate of phospholipid synthesis.
397 citations
TL;DR: This chapter discusses the metabolism of molecular species of diacylglycerophospholipids, which is intimately involved with the activity of the acyl transferases and can yield beneficial results in the treatment of membrane diseases.
Abstract: Publisher Summary This chapter discusses the metabolism of molecular species of diacylglycerophospholipids. The glycerolipid composition of cell membranes and lipoproteins is metabolically adjusted to meet specific requirements, and it does not merely reflect the supply of different fatty acids in the diet or in the cell culture medium. However, adequate adjustment cannot always be possible, and under such conditions, the cellular activity can take place in a suboptimal physicochemical environment and characteristic symptoms of a disease state can appear. As the cellular lipid composition is subject to considerable dietary and pharmacological manipulation, there can be therapeutic alterations in the composition of the molecular species of the tissues and other animal species. The metabolism of the molecular species of the glycerophospholipids is intimately involved with the activity of the acyl transferases. Therapeutic alterations in the composition of the molecular species of the glycerolipids can be feasible and can yield beneficial results in the treatment of membrane diseases.
313 citations
TL;DR: In this paper, isomers of cis-octadecenoic acid, with the double bond in each position in the hydrocarbon chain, were used to synthesize the corresponding 1,2-diacyl-sn-glycero-3phosphorylcholines (lecithins).
218 citations