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A. Paul Krapcho
Researcher at University of Vermont
Publications - 109
Citations - 1847
A. Paul Krapcho is an academic researcher from University of Vermont. The author has contributed to research in topics: Isoquinoline & Phenanthroline. The author has an hindex of 20, co-authored 109 publications receiving 1780 citations.
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Journal ArticleDOI
Synthetic applications and mechanism studies of the decarbalkoxylations of geminal diesters and related systems effected in dimethyl sulfoxide by water and/or by water with added salts
A. Paul Krapcho,J. F. Weimaster,J. M. Eldridge,Edwin G. E. Jahngen,A. J. Lovey,W. P. Stephens +5 more
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Mono-Protected Diamines. N-tert-Butoxycarbonyl-α,ω-Alkanediamines from α,ω-Alkanediamines
TL;DR: In this article, the authors report a convenient pathway to N-tert-butoxycarbonyl-α,ω-alkanediamines 2a-e [H2N(CH2)χNHBOC; χ=2, 3, 4, 5 and 6; (75-90% yields) by treatment of the corresponding α,ω-,alkanedienine with di-terto-butyl dicarbonate in dioxane as the solvent.
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Decarbalkoxylations of geminal diesters, β-keto esters and α-cyano esters effected by sodium chloride in dimethyl sulpoxide
A. Paul Krapcho,Allen J. Lovey +1 more
Journal ArticleDOI
The decarbethoxylation of geminal dicarbethoxy compounds.
Journal ArticleDOI
Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition
Claudia Sissi,Lorena Lucatello,A. Paul Krapcho,David J. Maloney,Matthew B. Boxer,Maria V. Camarasa,Gabriella Pezzoni,Ernesto Menta,Manlio Palumbo +8 more
TL;DR: A series of compounds related to PIPER, a well-known perylene-based telomerase inhibitor, are synthesized, modified the number of condensed aromatic rings and introduced different side chains to modulate drug protonation state and extent of self-aggregation.