Author
A. Soosai Manickam
Bio: A. Soosai Manickam is an academic researcher. The author has contributed to research in topics: Stability (learning theory) & Log-normal distribution. The author has an hindex of 1, co-authored 1 publications receiving 169 citations.
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TL;DR: In diabetic rats and diabetic rats fed with A. vera, no change was noticed in the kidney and stomach, while in streptozotocin-induced diabetic rats, the fasting plasma glucose levels were reduced to normal and body weight was found to be increased.
Abstract: An attempt was made to study the beneficial effects of Aloe vera (L.) Burm. fil. in streptozotocin-induced diabetic rats. In diabetic induced rats fed with A. vera (300 mg/kg body wt), the fasting plasma glucose levels were reduced to normal and body weight was found to be increased. In the pancreatic sections of diabetic rats fed with A. vera, the islets were comparable to normal rats. In liver, the changes caused after induction of diabetes are granular cytoplasm, dilated sinusoids, shrunken nuclei and inflammation, which was reduced after feeding with A. vera. Excess proliferation of epithelium in the small intestine was observed in diabetic rats, which was reduced after A. vera feeding. In diabetic rats and diabetic rats fed with A. vera, no change was noticed in the kidney and stomach.
176 citations
TL;DR: The concentration of prolactin in healthy persons is the focus of this investigation and the concentration of serum PRL in blood is determined by gender based, resulting in linked concentrations in men and women.
Abstract: The concentration of prolactin in healthy persons is the focus of this investigation. The concentration of serum PRL in blood is determined by gender based. Traditional employment, sleeping patterns, psychological stress, and medicine are maintained for both genders. As a result of the research, the concentrations of PRL in men and women are linked. Log-Normal distributions were employed in the Mathematical Model. The medical results were analysed using the mathematical model that corresponded to them.
TL;DR: In this paper , the authors considered a fractional-order neuron model under an electromagnetic field in terms of generalized Caputo fractional derivatives and numerically solved the problem by using a generalized version of the Euler method with stability and error analysis.
Abstract: Abstract This article considers a fractional-order neuron model under an electromagnetic field in terms of generalized Caputo fractional derivatives. The motivation for incorporating fractional derivatives in the previously proposed integer-order neuron model is that the fractional-order model impresses with efficient effects of the memory, and parameters with fractional orders can increase the model performance by amplifying a degree of freedom. The results on the uniqueness of the solution for the proposed neuron model are established using well-known theorems. The given model is numerically solved by using a generalized version of the Euler method with stability and error analysis. Several graphical simulations are performed to capture the variations in the membrane potential considering no electromagnetic field effects, various frequency brands of external forcing current, and the amplitude and frequency of the external magnetic radiation. The impacts of fractional-order cases are clearly justified.
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TL;DR: The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine.
Abstract: The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.
210 citations
TL;DR: The present investigation reports the efficacy of the gold nanoparticles as promising in the treatment of hyperglycemia and confirms that C. fistulagold nanoparticles have promising antidiabetic properties.
Abstract: Cassia fistula stem bark was used for the preparation of aqueous extract and synthesis of gold nanoparticles to evaluate the hypoglycemic effects of the plant. The synthesized gold nanoparticles were characterized by ultraviolet-visible spectroscopy for their absorbance pattern, Fourier transform infrared spectroscopy to identify possible functional groups, and scanning electron microscopy to determine the size of the nanoparticles. The present investigation reports the efficacy of the gold nanoparticles as promising in the treatment of hyperglycemia. Body weight, serum glucose concentrations, liver function tests, kidney function tests, and lipid profile were analyzed. A significantly larger decrease in serum biochemistry parameters and an increase in body weight, total protein levels, and high-density lipoprotein were observed in rats with streptozotocin-induced diabetes treated with gold nanoparticles than in the ones treated with the aqueous extract. The results of this study confirm that C. fistula gold nanoparticles have promising antidiabetic properties.
196 citations
TL;DR: Although, IL-1Ra has broad-spectrum anti-inflammatory activities, it also has some limitations due to its short half-life, and further studies are required to investigate its therapeutic effects against diabetes and diabetes-associated complications.
141 citations
TL;DR: An update of the findings from clinical research into medicinal plant therapy for T2DM is presented, finding bioactive molecules isolated from natural sources have been proven to lower blood glucose levels via regulating one or more of the following mechanisms.
Abstract: Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory responses and beta cell dysfunction. This ailment affects as many as 451 million people worldwide, and it is also one of the leading causes of death. In spite of the immense advances made in the development of orthodox antidiabetic drugs, these drugs are often considered not successful for the management and treatment of T2DM due to the myriad side effects associated with them. Thus, the exploration of medicinal herbs and natural products as therapeutic sources for the treatment of T2DM is promoted because they have little or no side effects. Bioactive molecules isolated from natural sources have been proven to lower blood glucose levels via regulating one or more of the following mechanisms: improvement of beta cell function, insulin resistance, glucose (re)absorption, and glucagon-like peptide-1 homeostasis. In recent times, the mechanisms of action of different bioactive molecules with antidiabetic properties and phytochemistry are gaining a lot of attention in the area of drug discovery. This review article presents an update of the findings from clinical research into medicinal plant therapy for T2DM.
127 citations
TL;DR: Findings of the present study suggest that the aqueous extract of leaves of MK, PG and CR at the dose of 500 mg/kg body weight brings about significant beneficial effects in various physiological/ histological parameters altered during diabetic manifestations and these effects are quite comparable with glibenclamide (a standard drug used to treat diabetes mellitus).
Abstract: Aqueous extract of leaves of 3 herbs (Murraya koenigii, MK; Psidium guajava, PG and Catharanthus roseus, CR) were used to test their antidiabetic activity in Streptozotocin (STZ) induced diabetic albino rats. MK, PG and CR are given to the STZ induced diabetic rats at the concentration of 500 mg/kg body weight in different groups of 6 diabetic rats each orally once a day for 15 days. Glibenclamide (GBC) is also given to another group to support the results at the concentration of 3 mg/kg body weight orally once a day for 15 days. Diabetic control received vehicle. Body weight showed significant increase (MK and PG: p<0.05, CR and GBC: p<0.001) after 15 days of treatment with herbal extract when compared with the control. Blood glucose level on 15th day of treatment become significantly low (p<0.001). At the termination of th e experiment (on 15th day) the urine glucose and ketone were absent in herbal treated group which was present in the diabetic control. Histological study of the pancreas also assesses the results of body weight and blood glucose level. Islets of diabetic control group were damaged, shrunken in size and infiltration of lymphocytes was observed. While islets of herbal extracts treated rats were comparable to normal rats. Many rounds and elongated islets were evenly distributed through out the cytoplasm. No significant histological alteration was found in glomeruli or any other segment of kidney tubule in STZ induced diabetic rats. In herbal extract treated group no difference was found in kidney tubules when compare with their respective diabetic control. Findings of the present study suggest that the aqueous extract of leaves of MK, PG and CR at the dose of 500 mg/kg body weight brings about significant beneficial effects in various physiological/ histological parameters altered during diabetic manifestations and these effects are quite comparable with glibenclamide (a standard drug used to treat diabetes mellitus).
101 citations