Author
A. Srinivas
Bio: A. Srinivas is an academic researcher from Kakatiya University. The author has contributed to research in topics: Thiomalic acid & Thioglycolic acid. The author has an hindex of 8, co-authored 16 publications receiving 175 citations.
Topics: Thiomalic acid, Thioglycolic acid, Cyclohexanone, Aryl, Catalysis
Papers
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TL;DR: A series of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles 6 were synthesized by the reaction of chalcone derivative ofmethylene- bis-thiazolidinone 5 with hydroxylamine hydrochloride and the chemical structures were elucidated by IR, 1H, 13C NMR, MS and elemental analyses.
53 citations
TL;DR: In this article, a series of novel methylene-bis-thiazolidinone derivatives was prepared by condensation of 5-(3-formyl-4-methoxybenzyl)-2-mETHObenzaldehyde 3 with mercapto acids and primary aromatic amines 4 in presence of ZnCl2 under both microwave irradiation and conventional heating conditions.
32 citations
TL;DR: In this article, a series of novel methylene-bis-pyrimidinyl-spiro-4thiazolidinones 6a-h have been synthesized by cyclocondensation of thioglycolic acid with methylene-(N-cyclohexylidene-N-Pyrimidine) 5a-H, which in turn have been prepared by the reaction of cyclohexanone with methylENE-bis 2-aminopyrimidines 4a-
24 citations
21 citations
TL;DR: Six new compounds synthesized by the reaction of arylidine derivative of methylene-bis-thiazolidinones 5a-c showed appreciable activity against test bacteria and fungi, and emerged as potential molecules for further development.
Abstract: A new series of bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2-(aryl)-3,3a,5,6-tetrahydro-2H pyrazolo[3,4-d][1,3]thiazol-5-yl]phenyl]methanes 6a―r was synthesized by the reaction of arylidine derivative of methylene-bis-thiazolidinones 5a-c with aryl/alkyl hydrazines. Chemical structures of all the new compounds were established by IR, 1 H-NMR, 13 C-NMR, MS and elemental data. The compounds 6a-r were evaluated for their nematicidal activity against Ditylenchus myceliophagus and Caenorhabdites elegans by aqueous in vitro screening technique. Amongst them compounds containing N-benzylpyrazole moiety (6d, 6j, 6p), and N-methylpyrazole moiety (6f, 6l, 6r) showed significant nematicidal activity against both the test nematodes with LD 50 160―210 ppm, almost equal to the oxamyl standard. Further, these compounds 6a―r were screened for their antibacterial (MZI, MIC and MBC) activity against three representative Gram-positive bacteria viz. Bacillus subtilis (MTCC 441), Bacillus sphaericus (MTCC 11), Staphylococcus aureus (MTCC 96) and three Gram-negative bacteria viz. Pseudomonas aeruginosa (MTCC 741), Klebsiella aerogenes (MTCC 39), Chromobacterium violaceum (MTCC 2656) and also screened for their antifungal (MZI, MIC and MFC) activity against four fungal organisms viz. Candida albicans (ATCC 10231), Aspergillus fumigatus (HIC 6094), Trichophyton rubrum (IFO 9185) and Trichophyton mentagrophytes (IFO 40996). Most of these new compounds showed appreciable activity against test bacteria and fungi, and emerged as potential molecules for further development.
14 citations
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TL;DR: It is expected that the fundamental properties of PILs will continue to be explored, along with continued interest in many existing and new applications, such as in electrochemistry, organic and inorganic synthesis, and biological applications.
Abstract: The thermal and physicochemical properties of protic ionic liquids (PILs) are reported. It is highly evident that there has been an extensive range of alkylammonium, imidazolium, and heterocyclic cations paired with many organic and inorganic anions that have been employed to prepare PILs. There has been strong interest in modifying the properties of PILs through the addition of water or other molecular solvents. For many applications, the presence of some water in the PILs is not detrimental, and instead leads to enhanced solvent properties such as lower viscosity, higher conductivities, and lower melting points. It remains an issue of definition though of how to refer to these resulting protic solutions. There is also an ongoing difficulty surrounding how to describe the proton activity in the PILs, analogous to pH in aqueous systems. For a broad range of applications, it has been reported that the acidity/basicity of the PIL or PIL-solvent system is crucial for their beneficial properties. It is expected that the fundamental properties of PILs will continue to be explored, along with continued interest in many existing and new applications, such as in electrochemistry, organic and inorganic synthesis, and biological applications. In particular, there has been a significant interest in a broad- range of PILs for use as electrolytes and incorporation in polymer electrolytes for fuel cells, and other energy storage devices.
676 citations
TL;DR: This review aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011 and presents data for active compounds, some of which have passed the preclinical testing stage.
328 citations
TL;DR: In this review article, the major focus has been paid to the applications of isoxazole compounds in treating multiple diseases, including anticancer, antimicrobial, anti-inflammatory, etc.
193 citations
TL;DR: This review is an endeavor to highlight the progress in the chemistry and biological activity of isoxazole derivatives which could provide a low-height flying bird’s eye view to the medicinal chemists for the development of clinically viable drugs using this information.
Abstract: Isoxazole, constituting an important family of five-membered heterocycles with one oxygen atom and one nitrogen atom at adjacent positions is of immense importance because of its wide spectrum of biological activities and therapeutic potential. It is, therefore, of prime importance that the development of new synthetic strategies and designing of new isoxazole derivatives should be based on the most recent knowledge emerging from the latest research. This review is an endeavor to highlight the progress in the chemistry and biological activity of isoxazole derivatives which could provide a low-height flying bird's eye view of isoxazole derivatives to the medicinal chemists for the development of clinically viable drugs using this information.
107 citations
TL;DR: Chalcones belong to the flavonoid family and constitute one of the major classes of naturally occurring oxygen heterocyclic compounds, leading to the synthesis of promising bioactive compounds as mentioned in this paper.
Abstract: Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The , -unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them to participate in addition reactions via attack to the carbonyl group (1,2-addition) or involving the -carbon (1,4-conjugate addition), leading to the synthesis of promising bioactive heterocyclic compounds. The purpose of this review is to present a systematic survey of the most recent literature that uses chalcones in the synthesis of biologically active 5and 6-membered nitrogen heterocycles such as pyrroles, indoles, isoxazoles, imidazoles, pyrazoles, indazoles, triazoles, tetrazoles, pyridines and pyrimidines. Efficiency, easy-to-handle and cheap reagents, alternative heating conditions and greener protocols will be highlighted. In this review we will cover the literature since the beginning of the 21 century in more than 400 publications.
77 citations