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A Surekha

Bio: A Surekha is an academic researcher from St. John's Medical College. The author has contributed to research in topics: Medicine & Health care. The author has an hindex of 5, co-authored 17 publications receiving 65 citations. Previous affiliations of A Surekha include Mahatma Gandhi Medical College & Research Institute & University of Hyderabad.

Papers
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Journal ArticleDOI
TL;DR: The LBMI group, considered to be going through chronic but mild undernutrition, showed higher repair capacity and exhibited no appreciable age-dependent decline in DNA-repair potential as was seen in normal subjects, confirming the observations made earlier in experimental animals.

25 citations

Journal ArticleDOI
TL;DR: The observations suggest that superficial dermatomycoses are an important cause of morbidity and should be carefully searched for especially in the elderly so that effective curative treatment can be instituted.
Abstract: Background: Dermatomycoses are more prevalent in India due to favourable climatic conditions, poverty, poor hygiene and overcrowding. Sparse published data are available regarding superficial dermatomycoses from India. Methods: In this prospective study, demographic characteristics, clinical spectrum and risk factors for the development were studied in 198 patients with superficial dermatomycoses. Results: Their mean age was 34.1 ± 15.3 years; there were 108 (54.5%) males. Majority of the patients (50.5%) belonged to upper-lower socio-economic status (Class IV as per modified Kuppuswamy’s classification). Most of the patients (69.7%) had presented with dermatophytoses. Among superficial dermatomycoses, tinea corporis was the most common (29.3%) clinical type. Potassium hydroxide mount was positive in 77.7% and culture was positive in 30.8%. Trichophyton rubrum was the most common species isolated (64%). Multivariable analysis using logistic regression revealed older age (> 50 years) to be an independent predictor for the development of tinea corporis (p<0.001). Conclusions: Our observations suggest that superficial dermatomycoses are an important cause of morbidity and should be carefully searched for especially in the elderly so that effective curative treatment can be instituted.

10 citations

Journal Article
TL;DR: Risks found to be significantly associated with postnatal depression were high risk pregnancy, being unhappy with in-laws, low income of the family, mood swings and low mood during pregnancy.
Abstract: Introduction: The Diagnostic and Statistical Manual of Mental Disorders (DSM) V defines Postpartum Depression (PND) as depression with onset within 4 weeks of delivery, symptoms lasting for a minimum of two weeks, causing clinically significant impairment of functioning. PND has important implications for the welfare of the family and the development of the child. Objectives were to determine the prevalence of postnatal depression among women attending a rural maternity hospital in South India and to identify the risk factors determining postnatal depression. Methodology: This was a cross sectional study, at a rural maternity hospital near Bangalore. One hundred and eighty women were selected through consecutive sampling. The Edinburg Postnatal Depression Scale (EPDS) was used administered to assess postnatal depression. Results: Prevalence of probable depression was found to be 18%. Risk factors found to be significantly associated with postnatal depression were high risk pregnancy, being unhappy with in-laws, low income of the family, mood swings and low mood during pregnancy. Conclusion: This study identified certain socio-demographic and obstetric risk factors for postnatal depressive symptoms in a rural community which helps to design intervention and preventive strategies for postpartum depression.

10 citations

Journal ArticleDOI
TL;DR: Non-governmental organizations are a basic element in the representation of the modern world and their participation in international organizations is in a way a guarantee of the latter's political legitimacy.
Abstract: Global health also refers to 'inherently global health issues', that is, health-determining phenomena that transcend national borders and political jurisdictions, such as globalization and climate change. NGOs include charitable and religious associations that mobilize private funds for development, distribute food and family planning services and promote community organization. They also include independent cooperatives, community associations, water-user societies, women’s groups and pastoral associations. To contribute to shared global health objectives, NGOs should work in close partnership with a wide array of international agencies and institutions to shape global health policies and to fund, implement, and evaluate programs. Non-governmental organizations are a basic element in the representation of the modern world. And their participation in international organizations is in a way a guarantee of the latter’s political legitimacy. From the stand point of global democratization, we need the participation of international public opinion and the mobilizing powers of non-governmental organizations .

8 citations

Journal ArticleDOI
TL;DR: A large number of the patients diagnosed with WRMDs have underlying musculoskeletal problems and the prognosis is poor for the patients’ physical and mental well-being.
Abstract: IntroductionWork-related musculoskeletal disorders (WRMDs) represent one of the most common and important occupational health problems in the working population; they negatively impact the quality ...

7 citations


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01 Apr 2003
TL;DR: In this paper, the authors used DSM-IV criteria to determine the presence since birth of depression (major or minor), panic disorder, acute adjustment disorder with anxiety (meeting the criteria for generalised anxiety disorder except for the duration criterion), and phobia.
Abstract: Although anxiety disorders are documented in the literature for new mothers (but less so for fathers), rates of postpartum caseness tend to include only those with depression when diagnostic interviews or self-report measures validated on such interviews are used. This methodology therefore underestimates the true percentage of women and men who experience significant psychological difficulties postpartum. This has implications for assessment, treatment and screening for postnatal mood disorders. Two studies were conducted on a total of 408 women and 356 men expecting their first child. They were recruited antenatally, and interviewed at 6 weeks postpartum using the Diagnostic Interview Schedule. DSM-IV criteria were applied to determine the presence since birth of depression (major or minor), panic disorder, acute adjustment disorder with anxiety (meeting the criteria for generalised anxiety disorder except for the duration criterion), and phobia. The inclusion of diagnostic assessment for panic disorder and acute adjustment disorder with anxiety increased the rates of caseness by between 57 and 100% for mothers, and 31-130% for fathers, over the rates for major or minor depression. Inclusion of assessment for phobia further increased the rates of disorder in both samples.

472 citations

Journal ArticleDOI
TL;DR: Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects that counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death.

430 citations

Journal ArticleDOI
TL;DR: A high prevalence of postpartum depression in Indian mothers is shown and more resources need to be allocated for capacity-building in maternal mental health care in India.
Abstract: Objective To provide an estimate of the burden of postpartum depression in Indian mothers and investigate some risk factors for the condition Methods We searched PubMed®, Google Scholar and Embase® databases for articles published from year 2000 up to 31 March 2016 on the prevalence of postpartum depression in Indian mothers The search used subject headings and keywords with no language restrictions Quality was assessed via the Newcastle-Ottawa quality assessment scale We performed the meta-analysis using a random effects model Subgroup analysis and meta-regression was done for heterogeneity and the Egger test was used to assess publication bias Findings Thirty-eight studies involving 20 043 women were analysed Studies had a high degree of heterogeneity (I2 = 968%) and there was evidence of publication bias (Egger bias = 258; 95% confidence interval, CI: 083-433) The overall pooled estimate of the prevalence of postpartum depression was 22% (95% CI: 19-25) The pooled prevalence was 19% (95% CI: 17-22) when excluding 8 studies reporting postpartum depression within 2 weeks of delivery Small, but non-significant differences in pooled prevalence were found by mother's age, geographical location and study setting Reported risk factors for postpartum depression included financial difficulties, presence of domestic violence, past history of psychiatric illness in mother, marital conflict, lack of support from husband and birth of a female baby Conclusion The review shows a high prevalence of postpartum depression in Indian mothers More resources need to be allocated for capacity-building in maternal mental health care in India

163 citations

Journal ArticleDOI
TL;DR: The evidence of the shared neuropathological events in these neurodegenerative diseases and the implication of cellular senescence in their onset or aggravation are summarized.
Abstract: Cellular senescence is a homeostatic biological process characterized by a permanent state of cell cycle arrest that can contribute to the decline of the regenerative potential and function of tissues. The increased presence of senescent cells in different neurodegenerative diseases suggests the contribution of senescence in the pathophysiology of these disorders. Although several factors can induce senescence, DNA damage, oxidative stress, neuroinflammation, and altered proteostasis have been shown to play a role in its onset. Oxidative stress contributes to accelerated aging and cognitive dysfunction stages affecting neurogenesis, neuronal differentiation, connectivity, and survival. During later life stages, it is implicated in the progression of cognitive decline, synapse loss, and neuronal degeneration. Also, neuroinflammation exacerbates oxidative stress, synaptic dysfunction, and neuronal death through the harmful effects of pro-inflammatory cytokines on cell proliferation and maturation. Both oxidative stress and neuroinflammation can induce DNA damage and alterations in DNA repair that, in turn, can exacerbate them. Another important feature associated with senescence is altered proteostasis. Because of the disruption in the function and balance of the proteome, senescence can modify the proper synthesis, folding, quality control, and degradation rate of proteins producing, in some diseases, misfolded proteins or aggregation of abnormal proteins. There is an extensive body of literature that associates cellular senescence with several neurodegenerative disorders including Alzheimer's disease (AD), Down syndrome (DS), and Parkinson's disease (PD). This review summarizes the evidence of the shared neuropathological events in these neurodegenerative diseases and the implication of cellular senescence in their onset or aggravation. Understanding the role that cellular senescence plays in them could help to develop new therapeutic strategies.

145 citations

Journal ArticleDOI
TL;DR: The data indicate that aging is characterized by a stochastic accumulation of molecular damage and a progressive failure of maintenance and repair, and the genes involved in homeodynamic pathways are the most likely candidate virtual gerontogenes.

102 citations