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A. V. Polikarpova
Researcher at Moscow State University
Publications - 16
Citations - 104
A. V. Polikarpova is an academic researcher from Moscow State University. The author has contributed to research in topics: Duchenne muscular dystrophy & Medicine. The author has an hindex of 4, co-authored 9 publications receiving 55 citations. Previous affiliations of A. V. Polikarpova include Russian Academy of Sciences.
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Journal ArticleDOI
CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene
Tatiana V. Egorova,Evgenia D. Zotova,Denis A. Reshetov,A. V. Polikarpova,Svetlana G. Vassilieva,Dmitry V. Vlodavets,Alexey A. Gavrilov,Sergey V. Ulianov,Sergey V. Ulianov,Vladimir L. Buchman,Alexei V. Deykin +10 more
TL;DR: A mouse model of the disease recapitulating a novel human mutation, a large de novo deletion of exons 8-34 of the DMD gene, found in a Russian DMD patient, is created, useful for validating therapies based on skipping exons that encode the N-terminal actin-binding domain.
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Immunomodulatory effects of progesterone and selective ligands of membrane progesterone receptors.
A. V. Polikarpova,Inna S. Levina,N.V. Sigai,Igor V. Zavarzin,I.A. Morozov,Petr M. Rubtsov,A. A. Guseva,O. V. Smirnova,T. A. Shchelkunova +8 more
TL;DR: The objective of this study was to examine the effects of P4 and new selective mPRs ligands on the expression of pro‐ and anti‐inflammatory cytokines in activated human peripheral blood mononuclear cells (PBMCs), THP‐1 monocyte cells, and Jurkat T cells.
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Selection of Progesterone Derivatives Specific to Membrane Progesterone Receptors.
A. V. Polikarpova,A. A. Maslakova,Inna S. Levina,L. E. Kulikova,Yury V. Kuznetsov,A. A. Guseva,T. A. Shchelkunova,Igor V. Zavarzin,O. V. Smirnova +8 more
TL;DR: Derivatives with an additional 19-hydroxyl group and removed 3-keto group had the highest selectivity for mPRs, suggesting these compounds as the most selective progesterone analogs for studying the mechanisms of progestin action via m PRs.
Journal ArticleDOI
Progesterone inhibits proliferation and modulates expression of proliferation-Related genes in classical progesterone receptor-negative human BxPC3 pancreatic adenocarcinoma cells.
Alexey I. Goncharov,Aitsana A. Maslakova,A. V. Polikarpova,Elena A. Bulanova,A. A. Guseva,I.A. Morozov,Petr M. Rubtsov,O. V. Smirnova,T. A. Shchelkunova +8 more
TL;DR: Results point to anti-proliferative effects of the progesterone high concentrations on BxPC3 cells and suggest that activation of mPRs may mediate this action.
Journal ArticleDOI
In vitro assay for the efficacy assessment of AAV vectors expressing microdystrophin.
Kirill A. Danilov,Svetlana G. Vassilieva,A. V. Polikarpova,Anna V. Starikova,A. Shmidt,Ivan I. Galkin,Alexandra A Tsitrina,Tatiana V. Egorova,Sergei N. Orlov,Sergei N. Orlov,Yuri Kotelevtsev +10 more
TL;DR: The in vitro system was shown to be capable of supporting studies on DMD gene therapy and ameliorated the disease phenotype and reduced the EPS-induced membrane damage to a level comparable to that of the healthy controls.