A
Aaron K. Neumann
Researcher at University of New Mexico
Publications - 31
Citations - 485
Aaron K. Neumann is an academic researcher from University of New Mexico. The author has contributed to research in topics: Glucan & Innate immune system. The author has an hindex of 13, co-authored 30 publications receiving 415 citations. Previous affiliations of Aaron K. Neumann include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Distribution and lateral mobility of DC-SIGN on immature dendritic cells--implications for pathogen uptake.
TL;DR: It is proposed that DC-SIGN clusters move from the leading edge–where the dendritic cell is likely to encounter pathogens in tissue–to a medial lamellar site where clusters enter the cell via endocytosis.
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Super-Resolution Imaging of C-Type Lectin and Influenza Hemagglutinin Nanodomains on Plasma Membranes Using Blink Microscopy
Michelle S. Itano,Christian Steinhauer,Jürgen J. Schmied,Carsten Forthmann,Ping Liu,Aaron K. Neumann,Nancy L. Thompson,Philip Tinnefeld,Ken Jacobson +8 more
TL;DR: What to the authors' knowledge is a novel domain structure emerges in which elemental nanodomains, potentially capable of binding viruses, are organized in a random fashion; evidently, these nanodOMains can be clustered into larger microdomains that act as receptor platforms for larger pathogens like yeasts.
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Mannan Molecular Substructures Control Nanoscale Glucan Exposure in Candida.
Matthew S. Graus,Michael J. Wester,Douglas W. Lowman,Douglas W. Lowman,David L. Williams,Michael Kruppa,Carmen Martinez,Jesse M. Young,Harry C. Pappas,Keith A. Lidke,Aaron K. Neumann +10 more
TL;DR: Investigating the role of specific N-mannan features in regulating the nanoscale geometry of glucan exposure in Candida albicans and C. glabrata found decreasing acid labile mannan abundance and α-(1,6)-mannan backbone length correlated most strongly with increased density and nanoscopic size of glucose exposure in C.albicans.
Journal ArticleDOI
DC-SIGN and influenza hemagglutinin dynamics in plasma membrane microdomains are markedly different.
Michelle S. Itano,Aaron K. Neumann,Ping Liu,Feng Zhang,Enrico Gratton,Wolfgang J. Parak,Nancy L. Thompson,Ken Jacobson +7 more
TL;DR: The surprising stability of DC-SIGN microdomains may reflect structural features that enhance pathogen uptake either by providing high-avidity platforms and/or by protecting against rapid microdomain endocytosis.
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Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment
TL;DR: The authors used direct stochastic optical reconstruction microscopy to explore the fine structure of β-glucan exposed on C. albicans cell walls before and after treatment with the antimycotic drug caspofungin, which alters glucan exposure.