Aaron Pollett

TL;DR: The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem Cells.

TL;DR: Combining DNA copy number alteration (CNA) profiling, sequencing, and lentiviral lineage tracking, this work followed the repopulation dynamics of 150 single lentivirus-marked lineages from 10 human colorectal cancers through serial xenograft passages in mice, showing that clones remained stable upon serial transplantation and Chemotherapy promoted the dominance of previously minor or dormant lineages.

TL;DR: Compared with the M probe, the FibroScan XL probe reduces TE failure and facilitates reliable LSM in obese patients, and lower liver stiffness cutoffs will be necessary when the XL probe is used to noninvasively assess liver fibrosis.

TL;DR: There is little value in testing for DNA mismatch repair loss in tumors, or for germline mismatch repair mutations, for colorectal cancers diagnosed in patients before age 60 years with an MSPath score <1 (approximately 50%).

TL;DR: A new mechanism of cancer progression is suggested in which mutations develop in a rapid burst after ablation of replication repair, which implies a threshold compatible with cancer-cell survival.