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Aaron R. Wheeler
Researcher at University of Toronto
Publications - 192
Citations - 12529
Aaron R. Wheeler is an academic researcher from University of Toronto. The author has contributed to research in topics: Digital microfluidics & Microfluidics. The author has an hindex of 60, co-authored 174 publications receiving 11068 citations. Previous affiliations of Aaron R. Wheeler include University of California, Los Angeles & York University.
Papers
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Journal ArticleDOI
Microfluidic device for single-cell analysis
Aaron R. Wheeler,William Throndset,Rebecca J. Whelan,Andrew M. Leach,Richard N. Zare,Yish Hann Liao,Kevin Farrell,Ian David Manger,Antoine Daridon +8 more
TL;DR: A novel microfluidic device constructed from poly(dimethylsiloxane) using multilayer soft lithography technology for the analysis of single cells is developed, achieving significant improvements in reagent consumption, analysis time, and temporal resolution over macroscale alternatives.
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Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis
Boyang Zhang,Miles Montgomery,M. Dean Chamberlain,Shinichiro Ogawa,Anastasia Korolj,Aric Pahnke,Laura A. Wells,Stéphane Massé,Jihye Kim,Lewis A. Reis,Abdul Momen,Sara S. Nunes,Sara S. Nunes,Aaron R. Wheeler,Kumaraswamy Nanthakumar,Gordon Keller,Michael V. Sefton,Milica Radisic +17 more
TL;DR: AngioChip cardiac tissues implanted via direct surgical anastomosis to the femoral vessels of rat hindlimbs establish immediate blood perfusion and it is shown that vascularized hepatic tissues and cardiac tissues engineered by using AngioChips process clinically relevant drugs delivered through the vasculature.
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Bio-microarray fabrication techniques--a review.
TL;DR: The current state of microarray fabrication is reviewed and technologies emerged from other applications and have the potential to increasemicroarray fabrication throughput; however, there are several challenges in applying them to micro array fabrication, including interference from satellite drops and biomolecule denaturization.
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Digital microfluidics for cell-based assays
TL;DR: Digital microfluidics (DMF) has great potential as a simple yet versatile analytical tool for implementing cell-based assays on the microscale because of automated manipulation of multiple reagents in addition to reduced reagent use and analysis time.
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The Digital Revolution: A New Paradigm for Microfluidics
TL;DR: In this paper, the authors review the state-of-the-art in digital microfluidics, with a discussion of device formats, actuation physics, and biological and non-biological applications.