Aarti Jagannath

TL;DR: Some of the emerging common mechanisms that link circadian rhythms, sleep and SCRD in severe mental illnesses are described and hold the promise of novel avenues for therapeutic intervention.

TL;DR: Analysis of the light-regulated transcriptome of the SCN has identified a key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting and provides a potential target for the regulation of circadian rhythms.

TL;DR: Treating clock disruption reverses and attenuates these adverse health states in animal models, thus establishing the circadian system as a novel therapeutic target, and focusing upon the genetics of circadian rhythms in sleep and health.

TL;DR: It is demonstrated that nocturnal light exposure can have either an arousal- or sleep-promoting effect, and that these responses are melanopsin-mediated via different neural pathways with different spectral sensitivities, which raise important questions relating to how artificial light may alter behaviour in both the work and domestic setting.

TL;DR: This chapter focuses on the retinal photoreceptors mediating entrainment, and how light information from the retina is transmitted to theSCN, before detailing recent advances in the understanding of how the molecular clock within the SCN is regulated by light input.