Author
Abdellah Alsaïdi
Bio: Abdellah Alsaïdi is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Reactivity (chemistry) & Alkoxy group. The author has an hindex of 6, co-authored 10 publications receiving 114 citations.
Papers
More filters
TL;DR: The oxazolidinone derivatives 2a-c displayed further in vivo antitumor activity in the hollow fiber assay and standard xenograft testing developed at the NCI.
47 citations
TL;DR: A series of 22 cyclopenta[c]thiophene related compounds were obtained by the pharmacomodulation of 6-amino-5,6-dihydro-4H-cyclopenta-4-ones 1a-g as discussed by the authors.
28 citations
TL;DR: Synthesis of some new hydroxyaminocyclopenta[c]thiophenones was achieved via halogenation reaction, then formation and finally cleavage of an aziridino ring, the importance of the ketohydroxyethylamino sequence for their activities is discussed.
Abstract: Synthesis of some new hydroxyaminocyclopenta[c]thiophenones was achieved via halogenation reaction, then formation and finally cleavage of an aziridino ring. The in vitro cytotoxic activity of these compounds was evaluated against L1210 leukemia. The importance of the ketohydroxyethylamino sequence for their activities is discussed.
12 citations
TL;DR: Treatment of 2-(2-formyl-1H-pyrrol-1-yl)-3-thiophenecarbonitrile by sodium percarbonate afforded, in a one-pot sequence and on a multigram scale, 5,6-dihydro-6-hydroxy-4H-polypoly(1,2-a]thieno-[3,2]-f][1,4]diazepin-4-one whose reactivity towards various nucleophiles like amines, hydrazines and thiols was
9 citations
TL;DR: In this paper, the reaction of 2-(2-formyl-1H-pyrrol-1-yl)-3-thiophene carbonitrile and 2-(1H 1H pyrrol, 1-yl) 3-thio-3 thiophene carboxamide was evaluated against various alkoxides.
8 citations
Cited by
More filters
409 citations
115 citations
TL;DR: In this paper, the factors that determine the site-selectivity of cross-coupling reactions of heteroaryl polyhalides with aryl boronates are discussed with a view to rationalising the trends found.
Abstract: Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
107 citations
TL;DR: A new class of amido linked bis heterocycles viz., pyrrolyl/pyrazolyl-oxazoles, thiazoles and imidazoles were prepared by 1,3-dipolar cycloaddition of TosMIC and diazomethane to the respective cinnamamide derivatives and screened for antimicrobial activity.
81 citations
TL;DR: This work was extended to study the potential role of the novel synthesized thiourea derivative 2a and benzo[b]tienopirimidina 3a, 5b, 6a and 8b as antidepressant, sedative or analgesic agents at two doses (15 or 30 mg kg-1 tjelesne mase).
Abstract: Heterocyclic antidepressants were the mainstay of antidepressant treatment fromtheir inception in the late 1950’s until the mid-1980’s. The development of synthetic he-terocyclic compounds as antidepressant, sedative or analgesic agents progressed consid-erably during the past decade (1–3). In recent years, the role of antidepressant drugs inthe management of different pain syndromes has elicited considerable interest (4, 5). Py-rimidine derivatives possessing anti-inflammatory, antidepressant and analgesic activi-ties have been reported in literature (6–8). Over the past few years, our research groupwas conducting a comprehensive program towards the synthesis of thiophenes andtheir fused derivatives (9–12). The importance of such compounds is based on their useas anti-flammatory (13, 14), anti-protozoal (15), and antitumor agents (16), templates for
75 citations