Abdellatif Chenite

TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.

TL;DR: It is demonstrated that chitosan solutions can be neutralised up to physiological pH (∼7.2) using β-glycerol phosphate without creating immediate gel-like precipitation and furthermore that subsequent heating of these solutions induces hydrogel formation.

TL;DR: Experiments showed that one intratumoral injection of the thermosensitive hydrogel containing paclitaxel was as efficacious as four intravenous injections of Taxol in inhibiting the growth of EMT-6 cancer cells in mice, but in a less toxic manner.

TL;DR: Results indicate that the chitosan/GP thermosensitive solutions gel rapidly at body temperature, can remain in the sol state at 4 degrees C and can sustain the delivery of macromolecules.

TL;DR: In this article, the authors proposed a self-setting compositions consisting in admixed liquid and solid components enable the formation of hardened bio-materials having a broad range of properties and performances.