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Author

Abdulaziz S. Bashammakh

Other affiliations: Umm al-Qura University
Bio: Abdulaziz S. Bashammakh is an academic researcher from King Abdulaziz University. The author has contributed to research in topics: Aptamer & Reagent. The author has an hindex of 23, co-authored 68 publications receiving 1951 citations. Previous affiliations of Abdulaziz S. Bashammakh include Umm al-Qura University.


Papers
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Journal ArticleDOI
15 Mar 2010-Talanta
TL;DR: A comprehensive review with 108 references referring to the distribution, source, accumulation, transformation, types and toxicity of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) is presented.

471 citations

Journal ArticleDOI
TL;DR: Studies on the interaction of C-dots with biomacromolecules are reviewed first, and recent developments of C -dots for target-specific bioimaging, drug delivery as well as theranostics development are highlighted and discussed.

277 citations

Journal ArticleDOI
TL;DR: A comprehensive review of liquid liquid microextraction (DLLME) techniques for analysis of trace emerging pesticides in water is presented in this paper, where thin-layer stripping voltammetric techniques at surface modified electrodes and spectrofluorimetric techniques coupled and implemented with DLLME are discussed.
Abstract: Dispersive liquid-liquid microextraction (DLLME) techniques have attracted considerable interest because they are cost effective, easy to operate, and reliably preconcentrate trace levels of analytes in complex matrices. This comprehensive review is concerned with principles, applications and developments of DLLME techniques for analysis of trace emerging pesticides in water. DLLME techniques have had few couplings to spectrofluorimetric methods and relatively none with electrochemical techniques. We highly recommend thin-layer stripping voltammetric techniques at surface-modified electrodes and spectrofluorimetric techniques coupled and implemented with DLLME. Great attention should be focused on developing low-cost, precise methods for analysis of trace concentrations of pesticides in various biological and environmental samples. We describe milestones and the combination of nanotechniques in the DLLME field, green aspects, advantages and shortcomings of known DLLME protocols.

129 citations

Journal ArticleDOI
TL;DR: The use of the tailed primers obviates the need for hapten labelling and consequent use of capture and reporter antibodies, whilst also avoiding theneed for any post-amplification processing for the generation of single stranded DNA, thus presenting an assay that can facilely find application at the point of need.
Abstract: Sensitive, specific, rapid, inexpensive and easy-to-use nucleic acid tests for use at the point-of-need are critical for the emerging field of personalised medicine for which companion diagnostics are essential, as well as for application in low resource settings. Here we report on the development of a point-of-care nucleic acid lateral flow test for the direct detection of isothermally amplified DNA. The recombinase polymerase amplification method is modified slightly to use tailed primers, resulting in an amplicon with a duplex flanked by two single stranded DNA tails. This tailed amplicon facilitates detection via hybridisation to a surface immobilised oligonucleotide capture probe and a gold nanoparticle labelled reporter probe. A detection limit of 1 × 10−11 M (190 amol), equivalent to 8.67 × 105 copies of DNA was achieved, with the entire assay, both amplification and detection, being completed in less than 15 minutes at a constant temperature of 37 °C. The use of the tailed primers obviates the need for hapten labelling and consequent use of capture and reporter antibodies, whilst also avoiding the need for any post-amplification processing for the generation of single stranded DNA, thus presenting an assay that can facilely find application at the point of need.

126 citations

Journal ArticleDOI
TL;DR: A comprehensive review on clean-up and recent advances in analysis of biogenic amines (BAs) in human body and dairy products of foodstuffs are presented in this paper, where a major focus on analysis of BAs revealed no use of coupling DLLME techniques with electroanalytical techniques in particular stripping voltammetry.
Abstract: In the past few years, we have seen intense interest grow in chemistry, toxicity and analysis of biogenic amines (BAs). Thus, a comprehensive review on clean-up and recent advances in analysis of biogenic amines (BAs) in human body and dairy products of foodstuffs are presented. Liquid-liquid extraction, solid phase extraction, solid phase microextraction, dispersive liquid-liquid microextraction (DLLME), cloud point extraction and hollow fiber-liquid phase microextraction represent the most common preconcentration techniques for BAs. HPLC, GC, TLC, spectrofluorimetry, capillary zone electrophoresis coupled with mass spectrometry are the most common analytical techniques used for analysis of BAs. DLLME techniques offer benefits over centrifugation, filtration and solid-phase extraction. The milestones and combination of nanotechniques in the DLLMEs field and green aspects of BAs in literature; advantages and drawbacks are addressed. A major focus on analysis of BAs revealed no use of coupling DLLME techniques with electroanalytical techniques in particular stripping voltammetry. Thus, voltammetric techniques at surface modified electrodes implemented with DLLME techniques is highly recommended for developing low cost and precise methods for analysis of BAs at ultra trace levels in foodstuffs. Conclusions have been drawn for future research is proposed.

85 citations


Cited by
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01 May 2005

2,648 citations

Journal ArticleDOI
TL;DR: The most relevant sources of nanoplastics are described and some insights into their fate once released into the environment are offered, including the most prominent effects of these small particulates, while identifying the key challenges scientists currently face in the research of nanopLastics in the environment.

699 citations

Book ChapterDOI
27 Jun 2018
TL;DR: In this article, the authors summarized the problems related to heavy metal pollution and various remediation technologies, and a case study in South Africa mines were also used to demonstrate the need for special attention to protect soil quality, air quality, water quality, human health, animal health and all spheres as a collection.
Abstract: The environment and its compartments have been severely polluted by heavy metals. This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment's ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.

527 citations

Journal ArticleDOI
TL;DR: The BBB structure is clearly depicts and various NPs‐mediated drug delivery systems according to different NPs species are described and the BBB penetration mechanisms are concluded in general, emphasized and investigated in each drug delivery system.

456 citations