Author
Abdur Rauf Khan
Bio: Abdur Rauf Khan is an academic researcher from Shandong University. The author has contributed to research in topics: Drug delivery & Nanocarriers. The author has an hindex of 11, co-authored 22 publications receiving 506 citations.
Papers
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TL;DR: This review aims to describe the latest development of brain targeted DDSs via nasal administration that directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics.
233 citations
TL;DR: This review comprehensively depicts challenges to the brain targeted drug delivery, mechanisms of drug transportation across the BBB, and potential contributions of endogenous cells as NPs delivery cells and novel targeting ligands decorated nanoformulations in imaging, treating and controlling neurological disorders.
122 citations
TL;DR: This work designed a novel redox/enzyme/ultrasound responsive chondroitin sulfate‐chlorin e6‐lipoic acid nanoplatform loading docetaxel, combining SDT and chemotherapy, for antiproliferation and antimetastasis of melanoma.
95 citations
TL;DR: An emphasis is focused on summarizing the novel insights and achievements of CPPs in surmounting the natural membrane barriers during the last 5 years.
81 citations
TL;DR: Redox/enzyme responsive chondroitin sulfate-ss-deoxycholic acid (CSCD) conjugates were synthesized using cystamine as the linkage which could self-assemble to form self-assembled nanoparticles in the aqueous environment to demonstrate promising nano-drug delivery systems for successful management of melanoma.
48 citations
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TL;DR: This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy and the potential ofSDT in combination with other modalities to address unmet needs in precision medicine.
Abstract: Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer. However, to be an effective anticancer treatment, it has to overcome limitations, such as low penetration depth, low target specificity, and resistance conferred by the local tumor microenvironment. As a non-invasive technique, low-intensity ultrasound has been widely used in clinical diagnosis as it exhibits deeper penetration into the body compared to light. Recently, sonodynamic therapy (SDT), a combination of low-intensity ultrasound with a chemotherapeutic agent (sonosensitizer), has been explored as a promising alternative for cancer therapy. As all known cancer treatments such as chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, and drug delivery have been advanced independently enough to complement others substantially, the combination of these therapeutic modalities with SDT is opportune. This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy. Also discussed is the potential of SDT in combination with other modalities to address unmet needs in precision medicine.
426 citations
TL;DR: This review presents some possibilities to enhance the drug penetration through the nasal barrier and summarizes some in vitro, ex vivo and in vivo technologies to test the drug delivery across the nasal epithelium into the brain.
393 citations
TL;DR: This short review presents recent developments in the field of cancer targeted drug delivery using magnetic nanocarriers as drug delivery systems and gives special attention to the pharmacokinetics and in vivo behavior of the developed nanoccarriers.
Abstract: Introduction: For many years, the controlled delivery of therapeutic compounds has been a matter of great interest in the field of nanomedicine. Among the wide amount of drug nanocarriers, magnetic...
298 citations
TL;DR: This review highlights the NLC with focus on the structure, the various fabrication techniques used and the characterization techniques which are critical in the development of a suitable and stable formulation.
293 citations
TL;DR: In this paper, a review of different characterization techniques for polymeric micelles is presented, from the ones used for the determination of micells basic characteristics (critical micellar concentration, size, surface charge, morphology) to the more complex approaches used to figure out micellers kinetic stability, drug release and behavior in the presence of biological substrates (fluids, cells and tissues).
264 citations