Abhishek Kumar

Bio: Abhishek Kumar is an academic researcher. The author has contributed to research in topics: Petroleum reservoir & Naproxen. The author has an hindex of 1, co-authored 2 publications receiving 3 citations.

Synthesis, anti-inflammatory and antimicrobial activity of some novel carboxamide derivatives of naproxen

Abstract: A series of novel substituted 2-(6-methoxynaphthalen-2-yl)-Nphenylpropanamide (NAJ1-NAJ8) have been synthesized upon refluxing 2-(6-methoxynaphthalen-2-yl) propanoic acid with different substituted anilines in the presence of dry redistilled pyridine and silicon tetrachloride as coupling reagent. The structures of the final synthesized compounds were confirmed by IR, 1 H NMR and mass spectra. The synthesized compounds were screened for their antibacterial and anti-inflammatory activities. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by cup plate method. Compounds NAJ2, NAJ3, NAJ4 and NAJ5 showed good antibacterial activity compared to the standard drug ciprofloxacin. Thus some of the amide prodrugs of naproxen showed good antibacterial activity compared to the parent drug naproxen. The synthesized compounds were screened for their anti-inflammatory activity by Carrageenan induced paw edema method. The amide prodrugs of naproxen NAJ1, NAJ3, NAJ4 and NAJ8 showed significant anti-inflammatory activity compared to the standard drug naproxen.

Darcy-and pore-scale issues associated with multi-phase fluid flow through a petroleum reservoir

Abstract: This manuscript primarily focuses on the constraints associated with the extended version of Darcy’s law that is used to describe the multiphase flow through a porous media; and in particular, a petroleum reservoir. This manuscript clearly brings out the basics associated with the usage of Darcy’s law, and reasons out the inapplicability of the Navier-Stokes Equation in order to describe the momentum conservation in a typical petroleum reservoir. Further, this work highlights the essence of continuum-based Darcy’s macroscopic-scale equation with that of Navier-Stokes’s microscopic-scale equation. Further, the absence of capillary forces in original Darcy’s equation and extending the same by considering the concept of ‘capillary pressure’ in order to accommodate the multi-phase flow has several critical constraints associated with it. In this manuscript, all these constraints or limitations have been posed in the form of a list of basic queries that need to be addressed or at least to be understood with clarity, when applying the multi-phase fluid flow equations associated with a petroleum reservoir. This study is limited to an oil-water two-phase system.

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents

Abstract: Background and aim: Naproxen is a member of the Nonsteroidal anti-inflammatory drugs (NSAIDs). This work aimed to synthesize a safe NSAID agent based on a peptide derivative. Methods: The structure of compounds 5-20 was established on the basis of spectral data. Frontier molecular orbitals and chemical reactivity were discussed to clarify inter- and intramolecular interactions among tested compounds. We applied competitive molecular docking using polynomial logarithms to identify the most accurate algorithm for pharmacological activity prediction for the tested compounds. The docking protocol with the lowest RMSD was selected for analyzing binding affinity. Results: Docking results illustrated that the binding interaction increased after introduction of an acidic fragment to the parent compound. These compounds were selected for additional study against adsorption, distribution, metabolism, excretion, and toxicity (ADMET) in silico. The compounds tested had good oral bioavailability without any carcinogenesis effect; no marked health effects were observed via rodent toxicity. Compounds passed through docking and ADMET profiles for them (5-16) were examined as anti-inflammatory and analgesic agents. Compounds 8 and 16 showed higher anti-inflammatory potency than the reference drug and tested compounds. Compounds 8, 10, and 14 exhibited the highest analgesic potency compared to the other tested compounds. Conclusion: The tested compounds have shown negligible ulcerogenic effects, and may be considered safer drugs than naproxen for treating inflammatory conditions.

Physicochemical Characterization and Analysis of Injection Water Quality During Waterflooding at Offshore Petroleum Facilities

Abstract: In this research, we study the physicochemical characterization of the injection water during water flooding and the changes in the water quality during its transportation from the Main injection pump (MIP) to the Well Head (WH) at the offshore platform in Mumbai High offshore field, India. The distance between the main injection pump and the well head is approximately 15 kilometers, connected by a subsea pipeline, which is long enough to degrade the quality of injection water during its transport. Physicochemical parameters such as pH, turbidity, cations, anions, filterability, iron content, Total suspended solids (TSS), Total dissolved solids (TDS) were determined from the industrial laboratory investigations. Cerini plots were graphed to determine the relative quality of water at MIP and injector. The result indicates the addition of solid content in the water during travel to wellhead. There is also a reduction in filterability from 6.45L/30 min to 3.43L/30 min. There has been increase in iron content from 0.01 mg/L to 6.85 mg/L. The research showed that there was deterioration in the quality of injection water during the transportation through the pipeline. An injection water treatment plant was recommended at the Mumbai High offshore platform after this study.