A
Abhishek Singh
Researcher at Government Medical College, Thiruvananthapuram
Publications - 251
Citations - 1857
Abhishek Singh is an academic researcher from Government Medical College, Thiruvananthapuram. The author has contributed to research in topics: Population & Haematopoiesis. The author has an hindex of 16, co-authored 232 publications receiving 1272 citations. Previous affiliations of Abhishek Singh include Indian Institute of Technology Delhi & Guru Gobind Singh Indraprastha University.
Papers
More filters
Journal ArticleDOI
Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation.
Deepika Awasthi,Sheela Nagarkoti,Amit Kumar,Megha Dubey,Abhishek Singh,Priya Pathak,Tulika Chandra,Manoj Kumar Barthwal,Madhu Dikshit +8 more
TL;DR: It is demonstrated for the first time that treatment of human PMNs with oxLDL or its various oxidized phopholipid component mediated NETs release, implying their role in the pathogenesis of inflammatory diseases such as SIRS.
Journal ArticleDOI
ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia
Joost H.A. Martens,Amit Mandoli,Femke Simmer,Bart-Jan Wierenga,Sadia Saeed,Abhishek Singh,Lucia Altucci,Edo Vellenga,Hendrik G. Stunnenberg +8 more
TL;DR: In this article, a genome-wide analysis revealed that both ERG and FLI1 occupied similar genomic regions as AML-1-ETO in t(8;21) AMLs and identified ERG/FLI1 as proteins that facilitate binding of oncofusion protein complexes.
Journal ArticleDOI
Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism.
Megha Dubey,Sheela Nagarkoti,Deepika Awasthi,Abhishek Singh,Tulika Chandra,Jagavelu Kumaravelu,Manoj Kumar Barthwal,Madhu Dikshit +7 more
TL;DR: A crucial role of NO/iNOS is suggested in neutrophil apoptosis via enhanced ROS generation and caspase-8 mediated activation of mitochondrial death pathway.
Journal ArticleDOI
CBFB–MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia
Amit Mandoli,Abhishek Singh,Pascal W.T.C. Jansen,Albertus T. J. Wierenga,H Riahi,Gianluigi Franci,Koen H.M. Prange,Sadia Saeed,Edo Vellenga,Michiel Vermeulen,Hendrik G. Stunnenberg,Joost H.A. Martens +11 more
TL;DR: An essential role for CBFβ–MYH11 is suggested in regulating the expression of genes involved in maintaining a stem cell phenotype through localizes to RUNX1 occupied promoters and interacts with TAL1, FLI1 and TBP-associated factors in the context of the hematopoietic transcription factors ERG, GATA2 and PU.
Journal ArticleDOI
Effects of Silicon and Silicon-Based Nanoparticles on Rhizosphere Microbiome, Plant Stress and Growth.
Vishnu D. Rajput,Tatiana Minkina,Morteza Feizi,Arpna Kumari,Masudulla Khan,Saglara Mandzhieva,Svetlana Sushkova,Hassan El-Ramady,Krishan K. Verma,Abhishek Singh,Eric D. van Hullebusch,Rupesh Kumar Singh,Hanuman Singh Jatav,Ravish Choudhary +13 more
TL;DR: In this article, the effects of nano-Si nanoparticles on soil microbes, soil properties, plant growth and various plant pathogens and diseases are summarized, where Si-NPs and Si are reported to change the microbial colonies and biomass, influence rhizospheric microbes and biomass content and are able to improve soil fertility.