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Abraham R. Tzafriri
Researcher at Massachusetts Institute of Technology
Publications - 62
Citations - 2151
Abraham R. Tzafriri is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Denervation & Drug delivery. The author has an hindex of 23, co-authored 61 publications receiving 1868 citations. Previous affiliations of Abraham R. Tzafriri include W. L. Gore and Associates & Shire plc.
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Journal ArticleDOI
Strut Position, Blood Flow, and Drug Deposition Implications for Single and Overlapping Drug-Eluting Stents
Brinda Balakrishnan,Abraham R. Tzafriri,Philip Seifert,Adam Groothuis,Campbell Rogers,Elazer R. Edelman +5 more
TL;DR: Simulations that coupled strut configurations with flow dynamics correlated with in vivo effects and revealed that drug deposition occurs less via contact between drug coating and the arterial wall than via flow-mediated deposition of blood-solubilized drug.
Journal ArticleDOI
Michaelis-Menten Kinetics at High Enzyme Concentrations
TL;DR: The total quasi-steady state approximation (tQSSA) for the irreversible Michaelis-Menten scheme is derived in a consistent manner and it is found that self-consistency of the initial transient guarantees the uniform validity of the tSSA.
Journal ArticleDOI
Luminal flow patterns dictate arterial drug deposition in stent-based delivery
Vijaya B. Kolachalama,Abraham R. Tzafriri,Davis Y. Arifin,Elazer R. Edelman,Elazer R. Edelman +4 more
TL;DR: Computational fluid dynamic modeling tools are employed to investigate the influence of luminal flow patterns on arterial drug deposition and distribution and explain how the disparity in sizes of the two recirculation zones and the asymmetry in drug distribution are determined by a complex interplay of local flow and strut geometry.
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Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis.
Krishna J. Rocha-Singh,Sue Duval,Michael R. Jaff,Peter Schneider,Gary M. Ansel,Sean P. Lyden,Christopher M. Mullin,John P. A. Ioannidis,Sanjay Misra,Abraham R. Tzafriri,Elazer R. Edelman,Juan F. Granada,Christopher J. White,Christopher J. White,Joshua A. Beckman +14 more
TL;DR: This individual patient data meta-analysis, based on the most complete available data set of mortality events from PTXD randomized controlled trials, identified an absolute 4.6% increased mortality risk associated withPTXD use.
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Stent elution rate determines drug deposition and receptor-mediated effects
TL;DR: Model predictions that tissue content linearly tracks stent elution rate were validated in porcine coronary artery sirolimus-eluting stents implants and receptor saturating drug doses are predicted to be most efficacious when eluted from stents in a constant zero order fashion as this maximizes the duration of elution and receptor saturation.