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Abu T.M. Serajuddin
Researcher at St. John's University
Publications - 133
Citations - 9037
Abu T.M. Serajuddin is an academic researcher from St. John's University. The author has contributed to research in topics: Solubility & Dosage form. The author has an hindex of 42, co-authored 128 publications receiving 8165 citations. Previous affiliations of Abu T.M. Serajuddin include Novartis & Bristol-Myers Squibb.
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Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
TL;DR: Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
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Salt formation to improve drug solubility.
TL;DR: Physicochemical principles of salt solubility are presented, with special reference to the influence of pH-solubility profiles of acidic and basic drugs on salt formation and dissolution.
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Trends in solubility of polymorphs
TL;DR: The general trend reveals that the ratio of polymorph solubility is typically less than 2, although occasionally higher ratios can be observed, and anhydrate/hydrate Solubility ratios appear to be more spread out and higher than the typical ratio for nonsolvated polymorphs.
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Application of melt extrusion in the development of a physically and chemically stable high-energy amorphous solid dispersion of a poorly water-soluble drug.
TL;DR: A novel method where the API was first converted to an amorphous form by solvent evaporation and then melt-extruded with a suitable polymer at a drug load of at least 20% w/w showed higher bioavailability than formulations containing the crystalline API.
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Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin
TL;DR: In this paper, the octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin(compactin), and simvastin (synvinolin)] were compared.