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Adalberto von Ancken

Bio: Adalberto von Ancken is an academic researcher. The author has contributed to research in topics: Artemia salina & Chemistry. The author has an hindex of 1, co-authored 4 publications receiving 6 citations.

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Journal ArticleDOI
TL;DR: In this article, the effects of homeopathic Mercurius corrosivus (MC) on Artemia salina cysts hatching and on mercury bioavailability were investigated using a model to identify aspects related to bioresilience.

4 citations

Journal ArticleDOI
21 Jul 2019
TL;DR: A canine clinical case with physycal and behavioural disturbances which, treated by its Simillimum (high-diluted medicine chosen by the similia principle), expressed the SLO as a latent psora manifestation and reached a cure status later.
Abstract: Symmetrical Lupoid Onycodystrophy (SLO) is a unusual immuno-mediated pathology with idiopathic etiology that can affect canine species. Differential diagnosis includes fungal, bacterial and autoimmune dermatitis and neoplasia. Histopathology is the main diagnostic technique, although it demands on the distal phalanx amputation. There are no predispositions regarding to dog’s breeds and the age of ill dogs can be from 3 to 8 years old. Clinical management can take up to six months to show some effect and has a uncertain prognosis. Homeopathy aims to patient well-being and miasm dynamics must be comprehended in order to set a correct prognosis evaluation. This article reports a canine clinical case with physycal and behavioural disturbances which, treated by its Simillimum (high-diluted medicine chosen by the similia principle), expressed the SLO as a latent psora manifestation and reached a cure status later. Homeopathy figure out as a great option to treat this illness condition.

3 citations

01 Jan 2019
TL;DR: The patient was followed up until 04/17/2019, the progression demonstrating the efficacy of homeopathic medicines for treatment of severe thrombocytopenia, without causing any side effect.
Abstract: We describe a case of homeopathic treatment for severe thrombocytopenia, associated with infection with Ehrlichia canis, corresponding to a 12-year-old Maltese female dog, replacing usual hospital treatment with steroids and platelet transfusion. On 28 January 2019 the patient presented thrombocytopenia—5,000 platelets/mm3—and petechiae on the dorsal and ventral regions, and also an extensive acute cervical hematoma. Treatment consisted of sequential administration of platelet biotherapy to stimulate platelet production and Phosphorus to check bleeding, as well as 2 doses of Lachesis muta also to control bleeding. The patient was followed up until 04/17/2019, the progression demonstrating the efficacy of homeopathic medicines for treatment of severe thrombocytopenia, without causing any side effect.

1 citations

Journal ArticleDOI
TL;DR: The main data suggest that aspirin 15 cH increases macrophage activity but presents a paradoxal effect when mixed with LPS, and succussed water itself has modulatory effects on macrophages.
Abstract: Background: Under LPS-stimulus, platelets can activate macrophages by a cell-to-cell contact or through cytokine degranulation. Rebound effects of anti-thrombotic agents, such as prostanoids and COX inhibitors can lead to thrombosis, infarct, and stroke. Aspirin has been prescribed for decades due to its powerful antiplatelet action, but it is also related to paradoxical effects such as withdrawal syndrome peaks, resistance, and thrombogenesis. Ultra-diluted aspirin can also produce the same effect in one hour, regardless of Cox-2, by still unknown pathways. Antithrombotic effects of aspirin are also reversed by its high dilutions. Aims: This study aims to characterize the effects of aspirin 15cH on macrophages challenged with LPS, a Cox-2 activator. Methodology: RAW 264.7 macrophages were sown in 24 wells plates using R10 medium, boosted with 1μg/ml LPS, and treated with aspirin 15 cH and controls. The activity was evaluated after 24 hours. Supernatants were evaluated for cytokines, nitric oxide, and dielectric oscillations, through solvatochromic dyes (Cartwright’s method). Results and discussion: macrophage spreading was increased by aspirin 15 cH, an LPS-like effect. Paradoxically, a significant reduction of this effect was noted when both, LPS and aspirin 15 cH, were added. Succussed water reversed the effect of LPS, leading to TNF (p<0.05) production close to baseline levels. Also, the single treatment with succussed water inhibited IL-10 production (p<0.05), but aspirin 200 µg/mL (positive control) highly increased it (p<0.0001), showing the validity of the model. Nitric oxide production was strengthened by LPS presence (p<0.0001), as expected, but partially downregulated after treatment with aspirin 200 µg/mL, water and succussed water. A pilot study with solvatochromic dyes showed no significant difference among treatments. Conclusion: The main data suggest that aspirin 15 cH increases macrophage activity but presents a paradoxal effect when mixed with LPS. On the other hand, succussed water itself has modulatory effects on macrophages.

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Journal ArticleDOI
TL;DR: CD 3, BLA 36, lysozyme, and MHC class II preserved significant antigenicity during formalin fixation and short decalcification for 24-48 hours, whereas CD 79alpha and particularly Mac 387 seemed to be more susceptible to denaturation by the decalCification process.
Abstract: The purpose of this study was to characterize the immunophenotype of the inflammatory infiltrate in canine lupoid onychodystrophy and to determine if decalcification interferes with immunoreactivity. Claw biopsies of 14 dogs with lupoid onychodystrophy were stained with CD3, BLA36 and HM57 (CD97α), MAC 387, lysozyme and MHC class II using an immunoperoxidase and avidin/biotin technique. Cells infiltrating the claw matrix were counted in two high-power fields; numbers were expressed as a percentage of the cellular infiltrate. The inflammatory infiltrate consisted predominantly of B and T cells; macrophages were typically only present in small numbers. There was no correlation between the predominant inflammatory cell and clinical parameters. CD3, BLA36, lysozyme and MHC II preserved significant antigenicity during formalin fixation and short decalcification, while staining for CD79A and particularly MAC 387 was less reliable. Prolonged decalcification of 7–14 days abolished immunostaining with all antibodies. Short decalcification periods allow immunostaining of samples with some antibodies (CD3, BLA36, lysozyme, MHC II), but not others (CD79A, MAC387), while prolonged decalcification prohibits immunostaining. The nature of the mononuclear infiltrate in lupoid onychodystrophy is not helpful clinically. This study was funded by the American Academy of Veterinary Dermatology.

7 citations

16 Oct 2015
TL;DR: Ehrlichiosis is one of the major infectious diseases, caused by a hemoparasite of Rickettsiales order and genus Ehrlichia spp., are obligate intracellular parasites of immature and mature hematopoietic cells.
Abstract: Ehrlichiosis is one of the major infectious diseases, caused by a hemoparasite of Rickettsiales order and genus Ehrlichia spp., Are obligate intracellular parasites of immature and mature hematopoietic cells. The main species that affects dogs is Ehrlichia canis. Transmission can occur through the participation of a vector, the tick Rhipicephalus sanguineus, or by blood transfusion. Infected with E. canis dogs may develop mild to intense signs or no signs, depending on the stage of the disease in which they are. Clinical diagnosis is usually not enough to confirm the disease, due to nonspecific clinical signs, so there is the need for additional diagnostic. Although a disease which can be very severe, treatment is simple and consists in the administration of antibiotics; Doxycycline is the antibiotic of choice. Its incidence has increased during the recent years in all regions of Brazil, so the need for more study and understanding of this disease.

7 citations

Journal ArticleDOI
TL;DR: In this paper, the authors analyzed 128 articles in order to summarize methods of stress assessment in different clinical and experimental environments, as well as methods to alleviate stress, and identified the most common forms of stress-related behavior in various situations.

3 citations

01 Jan 2010
TL;DR: Universidade Estadual Paulista Julio de Mesquita Filho campus Botucatu, Faculdade de Medicina Veterinaria e Zootecnia, Departamento de Clinica Veterinarian.
Abstract: Universidade Estadual Paulista Julio de Mesquita Filho campus Botucatu, Faculdade de Medicina Veterinaria e Zootecnia, Departamento de Clinica Veterinaria. Distrito de Rubiao Jr. Botucatu, SP - Brasil

2 citations

Journal ArticleDOI
TL;DR: Studies using immobilized Brooker's merocyanine with Arsenicum 10M reveal that the lifetime of the potency is much longer than expected and that its action consists of three distinct phases, suggesting a resonant interaction with the dye.

2 citations