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Adalbjorg Jonasdottir
Researcher at deCODE genetics
Publications - 32
Citations - 10119
Adalbjorg Jonasdottir is an academic researcher from deCODE genetics. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 23, co-authored 29 publications receiving 9123 citations. Previous affiliations of Adalbjorg Jonasdottir include Amgen.
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Journal ArticleDOI
Large recurrent microdeletions associated with schizophrenia
Hreinn Stefansson,Dan Rujescu,Sven Cichon,Olli Pietiläinen,Andres Ingason,Stacy Steinberg,Ragnheidur Fossdal,Engilbert Sigurdsson,Thordur Sigmundsson,Jacobine E. Buizer-Voskamp,Thomas Hansen,Thomas Hansen,Klaus D. Jakobsen,Klaus D. Jakobsen,Pierandrea Muglia,Clyde Francks,Paul M. Matthews,Arnaldur Gylfason,Bjarni V. Halldorsson,Daniel F. Gudbjartsson,Thorgeir E. Thorgeirsson,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Asgeir Björnsson,Sigurborg Mattiasdottir,Thorarinn Blondal,Magnús Haraldsson,Brynja B. Magnusdottir,Ina Giegling,Hans-Jürgen Möller,Annette M. Hartmann,Kevin V. Shianna,Dongliang Ge,Anna C. Need,Caroline Crombie,Gillian Fraser,Nicholas Walker,Jouko Lönnqvist,Jaana Suvisaari,Annamarie Tuulio-Henriksson,Tiina Paunio,T. Toulopoulou,Elvira Bramon,Marta Di Forti,Robin M. Murray,Mirella Ruggeri,Evangelos Vassos,Sarah Tosato,Muriel Walshe,Tao Li,Tao Li,Catalina Vasilescu,Thomas W. Mühleisen,August G. Wang,Henrik Ullum,Srdjan Djurovic,Ingrid Melle,Jes Olesen,Lambertus A. Kiemeney,Barbara Franke,Chiara Sabatti,Nelson B. Freimer,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Ole A. Andreassen,Roel A. Ophoff,Roel A. Ophoff,Alexander Georgi,Marcella Rietschel,Thomas Werge,Hannes Petursson,David Goldstein,Markus M. Nöthen,Leena Peltonen,Leena Peltonen,David A. Collier,David A. Collier,David St Clair,Kari Stefansson,Kari Stefansson +81 more
TL;DR: In a genome-wide search for CNVs associating with schizophrenia, a population-based sample was used to identify de novo CNVs by analysing 9,878 transmissions from parents to offspring and three deletions significantly associate with schizophrenia and related psychoses in the combined sample.
Journal ArticleDOI
Rate of de novo mutations and the importance of father’s age to disease risk
Augustine Kong,Michael L. Frigge,Gisli Masson,Søren Besenbacher,Søren Besenbacher,Patrick Sulem,Gisli Magnusson,Sigurjon A. Gudjonsson,Asgeir Sigurdsson,Aslaug Jonasdottir,Adalbjorg Jonasdottir,Wendy S.W. Wong,Gunnar Th. Sigurdsson,G. Bragi Walters,Stacy Steinberg,Hannes Helgason,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Agnar Helgason,Agnar Helgason,Olafur T. Magnusson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +24 more
TL;DR: A study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent–offspring trios at high coverage shows that the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child.
Journal ArticleDOI
Genetics of gene expression and its effect on disease
Valur Emilsson,Gudmar Thorleifsson,Bin Zhang,Amy Leonardson,Florian Zink,Jun Zhu,Sonia Carlson,Agnar Helgason,G. Bragi Walters,Steinunn Gunnarsdottir,Magali Mouy,Valgerdur Steinthorsdottir,Gudrun H. Eiriksdottir,Gyda Bjornsdottir,Inga Reynisdottir,Daniel F. Gudbjartsson,Anna Helgadottir,Aslaug Jonasdottir,Adalbjorg Jonasdottir,Unnur Styrkarsdottir,Solveig Gretarsdottir,Kristinn P. Magnusson,Hreinn Stefansson,Ragnheidur Fossdal,Kristleifur Kristjansson,Hjörtur Gislason,Tryggvi Stefansson,Björn Geir Leifsson,Unnur Thorsteinsdottir,John Lamb,Jeffrey R. Gulcher,Marc L. Reitman,Augustine Kong,Eric E. Schadt,Kari Stefansson +34 more
TL;DR: An extensive transcriptional network constructed from the human adipose data that exhibits significant overlap with similar network modules constructed from mouse adiposeData was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits.
Journal ArticleDOI
Variants conferring risk of atrial fibrillation on chromosome 4q25
Daniel F. Gudbjartsson,David O. Arnar,Anna Helgadottir,Solveig Gretarsdottir,Hilma Holm,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Adam Baker,Gudmar Thorleifsson,Kristleifur Kristjansson,Arnar Palsson,Thorarinn Blondal,Patrick Sulem,Valgerdur M Backman,Gudmundur A. Hardarson,Ebba Palsdottir,Agnar Helgason,Runa Sigurjonsdottir,Jon Th. Sverrisson,Konstantinos Kostulas,Maggie C.Y. Ng,Larry Baum,Wing-Yee So,Ka Sing Wong,Juliana C.N. Chan,Karen L. Furie,Steven M. Greenberg,Michelle Sale,Peter J. Kelly,Calum A. MacRae,Eric E. Smith,Jonathan Rosand,Jan Hillert,Ronald C.W. Ma,Patrick T. Ellinor,Gudmundur Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.
Journal ArticleDOI
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
Gudmar Thorleifsson,Kristinn P. Magnusson,Patrick Sulem,G. Bragi Walters,Daniel F. Gudbjartsson,Hreinn Stefansson,Thorlakur Jonsson,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Gerdur Stefansdottir,Gisli Masson,Gudmundur A. Hardarson,H. Petursson,Arsaell Arnarsson,Mehdi Motallebipour,Ola Wallerman,Claes Wadelius,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Fridbert Jonasson,Kari Stefansson +21 more
TL;DR: Two nonsynonymous SNPs in exon 1 of the gene LOXL1 explain the association with glaucoma, and the data suggest that they confer risk of XFG mainly through exfoliation syndrome (XFS).