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Adam Auton
Researcher at Albert Einstein College of Medicine
Publications - 109
Citations - 65100
Adam Auton is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 47, co-authored 94 publications receiving 51799 citations. Previous affiliations of Adam Auton include Broad Institute & Cornell University.
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Book ChapterDOI
Estimating recombination rates from genetic variation in humans.
Adam Auton,Gil McVean +1 more
TL;DR: The detection of recent crossover events in both well-characterised pedigrees and larger populations with extensive recent shared ancestry and approaches for learning about the fine-scale structure of recombination rate variation from patterns of genetic variation in unrelated individuals are discussed.
Journal ArticleDOI
Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations.
Yang Luo,Xinyi Li,Xin Wang,Steven Gazal,Steven Gazal,Josep M. Mercader,Josep M. Mercader,Benjamin M. Neale,Benjamin M. Neale,Jose C. Florez,Adam Auton,Adam Auton,Alkes L. Price,Alkes L. Price,Hilary K. Finucane,Soumya Raychaudhuri +15 more
TL;DR: In this article, a covariate-adjusted linkage disequilibrium score regression (cov-LDSC) was proposed to estimate SNP-heritability and its enrichment in homogenous and admixed populations with summary statistics and in-sample LD estimates.
Posted Content
Identifying recombination hotspots using population genetic data
TL;DR: This work presents a method for inferring the location of recombination hotspots from patterns of linkage disequilibrium within samples of population genetic data, and shows that it has hotspot detection power of approximately 50-60%, but depending on the magnitude of the hotspot.
Journal ArticleDOI
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways
Kyoko Watanabe,Philip R. Jansen,Jeanne E. Savage,Priyanka Nandakumar,Xin Wang,Michelle Agee,Stella Aslibekyan,Adam Auton,Robert K. Bell,Katarzyna Bryc,S. Clark,Sarah L. Elson,Kipper Fletez-Brant,Pierre Fontanillas,Nicholas A. Furlotte,P. Gandhi,Karl Heilbron,B. Hicks,Karen E. Huber,Ethan M. Jewett,Yunxuan Jiang,Aaron Kleinman,Keng-Han Lin,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Kimberly F. McManus,Joanna L. Mountain,Sahar V. Mozaffari,Elizabeth S. Noblin,Carrie A.M. Northover,Jared O'Connell,Steven J. Pitts,G. David Poznik,J. Fah Sathirapongsasuti,Janie F. Shelton,Jingchunzi Shi,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,R. Tunney,Vladimir Vacic,Wei Wang,David A. Hinds,Joel Gelernter,Daniel Levy,Renato Polimanti,Murray B. Stein,Eus J.W. Van Someren,August B. Smit,Danielle Posthuma +50 more
TL;DR: In this paper , the authors propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci, which yields specific hypotheses on underlying mechanisms of insomnia that would have been missed by traditional approaches.
Posted ContentDOI
Genome-wide study identifies 611 loci associated with risk tolerance and risky behaviors
Richard Karlsson Linnér,Richard Karlsson Linnér,Pietro Biroli,Edward Kong,S. Fleur W. Meddens,S. Fleur W. Meddens,Robbee Wedow,Mark Alan Fontana,Mark Alan Fontana,Maël Lebreton,Abdel Abdellaoui,Anke R. Hammerschlag,Michel G. Nivard,Aysu Okbay,Cornelius A. Rietveld,Pascal Timshel,Pascal Timshel,Stephen P. Tino,Maciej Trzaskowski,Ronald de Vlaming,Ronald de Vlaming,Christian L. Zund,Yanchun Bao,Laura Buzdugan,Ann H. Caplin,Chia-Yen Chen,Chia-Yen Chen,Peter Eibich,Peter Eibich,Peter Eibich,Pierre Fontanillas,Juan R. González,Peter K. Joshi,Ville Karhunen,Aaron Kleinman,Remy Z. Levin,Christina M. Lill,Gerardus A. Meddens,Gerard Muntané,Sandra Sanchez-Roige,Frank J. A. van Rooij,Erdogan Taskesen,Yang Wu,Futao Zhang,Adam Auton,Jason D. Boardman,David W. Clark,Andrew Conlin,Conor C. Dolan,Urs Fischbacher,Patrick J. F. Groenen,Kathleen Mullan Harris,Gregor Hasler,Albert Hofman,Albert Hofman,Mohammad Arfan Ikram,Sonia Jain,Robert Karlsson,Ronald C. Kessler,Maarten Kooyman,James MacKillop,Minna Männikkö,Carlos Morcillo-Suarez,Matthew B. McQueen,Klaus M. Schmidt,Melissa C. Smart,Matthias Sutter,Matthias Sutter,Roy Thurik,André G. Uitterlinden,Jon White,Harriet de Wit,Jian Yang,Lars Bertram,Lars Bertram,Dorret I. Boomsma,Tõnu Esko,Ernst Fehr,David A. Hinds,Magnus Johannesson,Meena Kumari,David Laibson,Patrik K. E. Magnusson,Michelle N. Meyer,Arcadi Navarro,Arcadi Navarro,Abraham A. Palmer,Tune H. Pers,Tune H. Pers,Danielle Posthuma,Daniel Schunk,Murray B. Stein,Rauli Svento,Henning Tiemeier,Paul R. H. J. Timmers,Patrick Turley,Patrick Turley,Patrick Turley,Robert J. Ursano,Gert G. Wagner,Gert G. Wagner,James F. Wilson,James F. Wilson,Jacob Gratten,James J. Lee,David Cesarini,Daniel J. Benjamin,Daniel J. Benjamin,Daniel J. Benjamin,Philipp Koellinger,Philipp Koellinger,Jonathan P. Beauchamp +111 more
TL;DR: Bioinformatics analyses imply that genes near general-risk-tolerance-associated SNPs are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission.