Adam M. Zysk

TL;DR: A brief history of OCT development is presented, current clinical applications are reviewed, some clinical translation challenges are discussed, and laboratory developments poised for future clinical application are reviewed.

TL;DR: In this paper, OCT images covering 1 cm 2 regions were acquired from surgical margins of lumpectomy specimens, registered with ink, and correlated with corresponding histologic sections, yielding a sensitivity of 100% and specificity of 82%.

TL;DR: Methods for the assessment of human breast tissue based on spatial and Fourier-domain analysis based on preliminary OCT data are presented, aimed at the development of automated diagnostic tools that will aid in the translation of this technology into the clinical environment.

TL;DR: In this translational study involving 35 patients, a handheld surgical OCT imaging probe was developed for in vivo use to assess margins both in the resection bed and on excised specimens for the microscopic presence of cancer, and image results from OCT showed structural differences between normal and cancerous tissue within the resections bed following WLE of the human breast.

TL;DR: Intraoperative optical imaging of specimen margins with a handheld probe potentially eliminates the majority of reoperations in patients with early-stage breast cancer and could potentially have been avoided in these patients.