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Adaoha E. C. Ihekwaba
Researcher at Norwich Research Park
Publications - 21
Citations - 1456
Adaoha E. C. Ihekwaba is an academic researcher from Norwich Research Park. The author has contributed to research in topics: Clostridium botulinum & Stochastic modelling. The author has an hindex of 7, co-authored 20 publications receiving 1370 citations. Previous affiliations of Adaoha E. C. Ihekwaba include University of Trento & Virginia Tech.
Papers
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Journal ArticleDOI
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
David E. Nelson,Adaoha E. C. Ihekwaba,M Elliott,James R. Johnson,C. A. Gibney,B. E. Foreman,Glyn Nelson,Violaine Sée,Caroline A. Horton,David G. Spiller,Steven W. Edwards,H. P. McDowell,John Unitt,Elaine Sullivan,Rachel L. Grimley,Neil Benson,David S. Broomhead,Douglas B. Kell,Michael R. H. White +18 more
TL;DR: Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription.
Journal ArticleDOI
Sensitivity analysis of parameters controlling oscillatory signalling in the NF-/sub K/Bpathway: the roles of IKK and I/sub K/B/sub alpha/
TL;DR: In this article, a model of the nuclear factor, κB (NF-κB) signalling pathway, containing 64 parameters and 26 variables, including steps in which the activation of the NF-κb transcription factor is intimately associated with the phosphorylation and ubiquitination of its inhibitor by a membrane-associated kinase, and its translocation from the cytoplasm to the nucleus.
Journal ArticleDOI
Synergistic control of oscillations in the NF-kappaB signalling pathway.
Adaoha E. C. Ihekwaba,David S. Broomhead,Rachel L. Grimley,Neil Benson,Michael R. H. White,Douglas B. Kell +5 more
TL;DR: Analysis of dynamic models of part of the NF-kappaB signalling pathway reveals a level of complexity in these dynamic models that is not apparent from study of their individual parameters alone and point to the value of manipulating multiple elements of complex networks to achieve desired physiological effects.
Journal ArticleDOI
Calibration of dynamic models of biological systems with KInfer
Paola Lecca,Alida Palmisano,Alida Palmisano,Adaoha E. C. Ihekwaba,Corrado Priami,Corrado Priami +5 more
TL;DR: This paper aims to ensure an inference model that deduces the rate constants of a system of biochemical reactions from experimentally measured time courses of reactants.
Journal ArticleDOI
Bridging the gap between in silico and cell-based analysis of the nuclear factor-kappaB signaling pathway by in vitro studies of IKK2.
Adaoha E. C. Ihekwaba,Adaoha E. C. Ihekwaba,Stephen J. Wilkinson,Dominic Waithe,David S. Broomhead,Peter Li,Rachel L. Grimley,Neil Benson +7 more
TL;DR: Analysis of the behavior of NF‐κB and its signal transduction network and its kinetics found that the values for the affinity and catalytic efficiency of IKK2 for IκBα were dependent on assay conditions, and application of these kinetic parameters resulted in significant differences in the oscillatory patterns of NF-κB depending on the rate constant value used.