Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy and histopathological examination. Automated classification of skin lesions using images is a challenging task owing to the fine-grained variability in the appearance of skin lesions. Deep convolutional neural networks (CNNs) show potential for general and highly variable tasks across many fine-grained object categories. Here we demonstrate classification of skin lesions using a single CNN, trained end-to-end from images directly, using only pixels and disease labels as inputs. We train a CNN using a dataset of 129,450 clinical images-two orders of magnitude larger than previous datasets-consisting of 2,032 different diseases. We test its performance against 21 board-certified dermatologists on biopsy-proven clinical images with two critical binary classification use cases: keratinocyte carcinomas versus benign seborrheic keratoses; and malignant melanomas versus benign nevi. The first case represents the identification of the most common cancers, the second represents the identification of the deadliest skin cancer. The CNN achieves performance on par with all tested experts across both tasks, demonstrating an artificial intelligence capable of classifying skin cancer with a level of competence comparable to dermatologists. Outfitted with deep neural networks, mobile devices can potentially extend the reach of dermatologists outside of the clinic. It is projected that 6.3 billion smartphone subscriptions will exist by the year 2021 (ref. 13) and can therefore potentially provide low-cost universal access to vital diagnostic care.

Dermatologist-level classification of skin cancer with deep neural networks

CA : A Cancer Journal for Clinicians

2005년 대한 생화학·분자생물학회 하계학술대회를 다녀와서

Differential Evolution (DE) is arguably one of the most powerful and versatile evolutionary optimizers for the continuous parameter spaces in recent times. Almost 5 years have passed since the first comprehensive survey article was published on DE by Das and Suganthan in 2011. Several developments have been reported on various aspects of the algorithm in these 5 years and the research on and with DE have now reached an impressive state. Considering the huge progress of research with DE and its applications in diverse domains of science and technology, we find that it is a high time to provide a critical review of the latest literatures published and also to point out some important future avenues of research. The purpose of this paper is to summarize and organize the information on these current developments on DE. Beginning with a comprehensive foundation of the basic DE family of algorithms, we proceed through the recent proposals on parameter adaptation of DE, DE-based single-objective global optimizers, DE adopted for various optimization scenarios including constrained, large-scale, multi-objective, multi-modal and dynamic optimization, hybridization of DE with other optimizers, and also the multi-faceted literature on applications of DE. The paper also presents a dozen of interesting open problems and future research issues on DE.

Recent advances in differential evolution – An updated survey

Image-based computer aided diagnosis systems have significant potential for screening and early detection of malignant melanoma. We review the state of the art in these systems and examine current practices, problems, and prospects of image acquisition, pre-processing, segmentation, feature extraction and selection, and classification of dermoscopic images. This paper reports statistics and results from the most important implementations reported to date. We compared the performance of several classifiers specifically developed for skin lesion diagnosis and discussed the corresponding findings. Whenever available, indication of various conditions that affect the technique's performance is reported. We suggest a framework for comparative assessment of skin cancer diagnostic models and review the results based on these models. The deficiencies in some of the existing studies are highlighted and suggestions for future research are provided.

/pdf/computer-aided-diagnostic-support-system-for-skin-cancer-a-1038pd88le.pdf

Computer Aided Diagnostic Support System for Skin Cancer: A Review of Techniques and Algorithms

https://opus.lib.uts.edu.au/bitstream/10453/32426/1/anam_activeexoskeleton.pdf

Active Exoskeleton Control Systems: State of the Art

One of the fundamental motivations for feature selection is to overcome the curse of dimensionality problem. This paper presents a novel feature selection method utilizing a combination of differential evolution (DE) optimization method and a proposed repair mechanism based on feature distribution measures. The new method, abbreviated as DEFS, utilizes the DE float number optimizer in the combinatorial optimization problem of feature selection. In order to make the solutions generated by the float-optimizer suitable for feature selection, a roulette wheel structure is constructed and supplied with the probabilities of features distribution. These probabilities are constructed during iterations by identifying the features that contribute to the most promising solutions. The proposed DEFS is used to search for optimal subsets of features in datasets with varying dimensionality. It is then utilized to aid in the selection of Wavelet Packet Transform (WPT) best basis for classification problems, thus acting as a part of a feature extraction process. Practical results indicate the significance of the proposed method in comparison with other feature selection methods.

Feature subset selection using differential evolution and a statistical repair mechanism

Developing accurate and powerful electromyogram (EMG) driven prostheses controllers that can provide the amputees with effective control on their artificial limbs, has been the focus of a great deal of research in the past few years. One of the major challenges in such research is extracting an informative subset of features that can best discriminate between the different forearm movements. In this paper, a new dimensionality reduction method, referred to as orthogonal fuzzy neighborhood discriminant analysis (OFNDA), is proposed as a response to such a challenge. Unlike existing attempts in fuzzy linear discriminant analysis, the objective of the proposed OFNDA is to minimize the distance between samples that belong to the same class and maximize the distance between the centers of different classes, while taking into account the contribution of the samples to the different classes. The proposed OFNDA is validated on EMG datasets collected from seven subjects performing a range of 5 to 10 classes of forearm movements. Practical results indicate the significance of OFNDA in comparison to many other feature projection methods (including locality preserving and uncorrelated variants of discriminant analysis) with accuracies ranging from 97.66% to 87.84% for 5 to 10 classes of movements, respectively, using only two EMG electrodes.

Orthogonal Fuzzy Neighborhood Discriminant Analysis for Multifunction Myoelectric Hand Control

The extraction of the accurate and efficient descriptors of muscular activity plays an important role in tackling the challenging problem of myoelectric control of powered prostheses. In this paper, we present a new feature extraction framework that aims to give an enhanced representation of muscular activities through increasing the amount of information that can be extracted from individual and combined electromyogram (EMG) channels. We propose to use time-domain descriptors (TDDs) in estimating the EMG signal power spectrum characteristics; a step that preserves the computational power required for the construction of spectral features. Subsequently, TDD is used in a process that involves: 1) representing the temporal evolution of the EMG signals by progressively tracking the correlation between the TDD extracted from each analysis time window and a nonlinearly mapped version of it across the same EMG channel and 2) representing the spatial coherence between the different EMG channels, which is achieved by calculating the correlation between the TDD extracted from the differences of all possible combinations of pairs of channels and their nonlinearly mapped versions. The proposed temporal-spatial descriptors (TSDs) are validated on multiple sparse and high-density (HD) EMG data sets collected from a number of intact-limbed and amputees performing a large number of hand and finger movements. Classification results showed significant reductions in the achieved error rates in comparison to other methods, with the improvement of at least 8% on average across all subjects. Additionally, the proposed TSDs achieved significantly well in problems with HD-EMG with average classification errors of <5% across all subjects using windows lengths of 50 ms only.

Adel Al-Jumaily

Papers

Computer Aided Diagnostic Support System for Skin Cancer: A Review of Techniques and Algorithms

Active Exoskeleton Control Systems: State of the Art

Feature subset selection using differential evolution and a statistical repair mechanism

Orthogonal Fuzzy Neighborhood Discriminant Analysis for Multifunction Myoelectric Hand Control

A Framework of Temporal-Spatial Descriptors-Based Feature Extraction for Improved Myoelectric Pattern Recognition