Adel Giaid

TL;DR: Preliminary results suggest that pulmonary hypertension is associated with the increased expression of endothelin-1 in vascular endothelial cells, suggesting that the local production of endethelin- 1 may contribute to the vascular abnormalities associated with this disorder.

TL;DR: It is possible that decreased expression of nitric oxide synthase may contribute to pulmonary vasoconstriction and to the excessive growth of the tunica media observed in this disease.

TL;DR: Findings indicate an essential role for EDNRB in the development of two neural crest-derived cell lineages, myenteric ganglion neurons and epidermal melanocytes, and postulate that defects in the human ED NRB gene cause a hereditary form of Hirschsprung's disease that has recently been mapped to human chromosome 13.

TL;DR: It is reported that a targeted disruption of the mouse endothelin-3 ligand (EDN3) gene produces a similar recessive phenotype of megacolon and coat color spotting, and postulate that defects in the human EDN3 gene may cause Hirschsprung's disease.

TL;DR: The identification of ECE-1 is reported, a novel membrane-bound neutral metalloprotease that is expressed abundantly in endothelial cells in vivo and is structurally related to neutral endopeptidase 24.11 and Kell blood group protein.