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Adele Stewart
Researcher at Florida Atlantic University
Publications - 35
Citations - 680
Adele Stewart is an academic researcher from Florida Atlantic University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 28 publications receiving 477 citations. Previous affiliations of Adele Stewart include Vanderbilt University & University of Iowa.
Papers
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Journal ArticleDOI
RGS6, a Modulator of Parasympathetic Activation in Heart
Jianqi Yang,Jie Huang,Biswanath Maity,Zhan Gao,Ramón A. Lorca,Hjalti Gudmundsson,Jingdong Li,Adele Stewart,Paari Dominic Swaminathan,Stella-Rita C Ibeawuchi,Andrew J. Shepherd,Ching Kang Chen,William Kutschke,Peter J. Mohler,Durga P. Mohapatra,Mark E. Anderson,Rory A. Fisher +16 more
TL;DR: In this paper, the specific contribution of RGS6 as an essential regulator of parasympathetic signaling in heart was examined, particularly in sinoatrial and atrioventricular nodal regions.
Book ChapterDOI
Introduction: G Protein-coupled Receptors and RGS Proteins.
Adele Stewart,Rory A. Fisher +1 more
TL;DR: This book summarizes recent advances employing modified model organisms that reveal RGS protein functions in vivo, providing evidence that R GS protein modulation of G protein signaling and GPCR can be as important as initiation of signaling by GPCRs.
Journal ArticleDOI
G-protein Inactivator RGS6 Mediates Myocardial Cell Apoptosis and Cardiomyopathy Caused By Doxorubicin
Jianqi Yang,Biswanath Maity,Jie Huang,Zhan Gao,Adele Stewart,Robert M. Weiss,Mark E. Anderson,Rory A. Fisher +7 more
TL;DR: RGS6 is identified as an essential mediator of the pathogenic responses to doxorubicin in heart, and it is argued that RGS6 inhibition offers a rational means to circumvent doxorbicin cardiotoxicity in human patients with cancer.
Journal ArticleDOI
Regulator of G Protein Signaling 6 (RGS6) Protein Ensures Coordination of Motor Movement by Modulating GABAB Receptor Signaling
Biswanath Maity,Adele Stewart,Jianqi Yang,Lipin Loo,David Sheff,Andrew J. Shepherd,Durga P. Mohapatra,Rory A. Fisher +7 more
TL;DR: These results establish RGS6 as a key component of GABABR signaling and represent the first demonstration of an essential role for modulatory actions of RGS proteins in adult cerebellum.
Journal ArticleDOI
Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol
Adele Stewart,Biswanath Maity,Simon P. Anderegg,Chantal Allamargot,Jianqi Yang,Rory A. Fisher +5 more
TL;DR: It is proposed that inhibition of RGS6 might represent a viable means to reduce alcohol cravings and withdrawal in human patients, while simultaneously protecting the heart and liver from further damage upon relapse.