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Adeline Su Lyn Ng
Researcher at Tan Tock Seng Hospital
Publications - 8
Citations - 103
Adeline Su Lyn Ng is an academic researcher from Tan Tock Seng Hospital. The author has contributed to research in topics: Frontotemporal dementia & Dementia. The author has an hindex of 4, co-authored 8 publications receiving 40 citations. Previous affiliations of Adeline Su Lyn Ng include National University of Singapore.
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Journal ArticleDOI
Utility of plasma Neurofilament light as a diagnostic and prognostic biomarker of the postural instability gait disorder motor subtype in early Parkinson’s disease
Adeline Su Lyn Ng,Adeline Su Lyn Ng,Yi Jayne Tan,Alisa Cui Wen Yong,Seyed Ehsan Saffari,Zhonghao Lu,Ebonne Yulin Ng,Samuel Yong-Ern Ng,Nicole Shuang-Yu Chia,Xinyi Choi,Dede Heng,Shermyn Neo,Zheyu Xu,Nicole C Keong,Nicole C Keong,Kay Yaw Tay,Wing Lok Au,Louis C.S. Tan,Eng-King Tan,Eng-King Tan +19 more
TL;DR: Higher NfL associated significantly with worse global cognition and UPDRS motor scores at baseline, and was able to predict motor and cognitive decline at a mean follow-up duration of 1.9 years, controlled for age, sex and disease duration.
Journal ArticleDOI
Distinct network topology in Alzheimer's disease and behavioral variant frontotemporal dementia.
Adeline Su Lyn Ng,Adeline Su Lyn Ng,Juan Wang,Kwun Kei Ng,Joanna Su Xian Chong,Xing Qian,Joseph Lim,Yi Jayne Tan,Yi Jayne Tan,Alisa Cui Wen Yong,Russell J. Chander,Shahul Hameed,Shahul Hameed,Simon Kang Seng Ting,Simon Kang Seng Ting,Nagaendran Kandiah,Nagaendran Kandiah,Juan Helen Zhou +17 more
TL;DR: In this article, the authors applied graph theoretical analysis to characterize network integration, segregation, and module distinctiveness (degree centrality, nodal efficiency, within-module degree, and participation coefficient) in Alzheimer's disease, bvFTD, and healthy participants.
Journal ArticleDOI
Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment
Ashwati Vipin,Heidi Jing Ling Foo,Joseph Lim,Russell J. Chander,Ting Ting Yong,Adeline Su Lyn Ng,Shahul Hameed,Simon Kang Seng Ting,Juan Zhou,Juan Zhou,Nagaendran Kandiah +10 more
TL;DR: Although WMH volume was highest in AD subjects, it had a more pervasive influence on brain structure and cognitive impairment in MCI, highlighting the importance of early detection of cerebrovascular disease, as its intervention at the MCI stage might potentially slow down neurodegeneration.
Journal ArticleDOI
Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease.
Adeline Su Lyn Ng,Adeline Su Lyn Ng,Yi Jayne Tan,Zhonghao Lu,Ebonne Yulin Ng,Samuel Yong-Ern Ng,Nicole Shuang-Yu Chia,Fiona Setiawan,Zheyu Xu,Nicole C Keong,Nicole C Keong,Kay Yaw Tay,Wing Lok Au,Louis C.S. Tan,Eng-King Tan,Eng-King Tan +15 more
TL;DR: It is found that UCHL1 correlates with motor function in PD, with higher levels seen in later disease stages, and these findings will be validated in longitudinal studies.
Journal ArticleDOI
Medial Temporal Atrophy in Amyloid-Negative Amnestic Type Dementia Is Associated with High Cerebral White Matter Hyperintensity.
Benjamin Yi Xin Wong,Ting Ting Yong,Levinia Lim,Jayne Yi Tan,Adeline Su Lyn Ng,Simon Kang Seng Ting,Shahul Hameed,Kok Pin Ng,Juan Helen Zhou,Nagaendran Kandiah +9 more
TL;DR: It is demonstrated that MTA is associated with greater CVD burden among Aβ-negative patients with amnestic type dementia, which has implications on clinical management strategies, where measures to reduce CVD may slow neurodegeneration and disease progression.