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Aditya Murthy

Researcher at Genentech

Publications -  26
Citations -  8367

Aditya Murthy is an academic researcher from Genentech. The author has contributed to research in topics: Autophagy & Innate immune system. The author has an hindex of 17, co-authored 24 publications receiving 6724 citations. Previous affiliations of Aditya Murthy include University Health Network & Ontario Institute for Cancer Research.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Metalloproteinases and their natural inhibitors in inflammation and immunity

Rama Khokha, +2 more
- 01 Sep 2013 - 
TL;DR: The metalloproteinase family is discussed as a crucial component in immune cell development and function and together with their endogenous inhibitors TIMPs (tissue inhibitor of metallofiltration) regulate signalling downstream of the tumour necrosis factor receptor and the interleukin-6 receptor.
Journal ArticleDOI

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

Aditya Murthy, +10 more
- 27 Feb 2014 - 
TL;DR: It is demonstrated that caspase 3 activation in the presence of a common risk allele leads to accelerated degradation of ATG16L1, placing cellular stress, apoptotic stimuli and impaired autophagy in a unified pathway that predisposes to Crohn’s disease.
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iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

David R. McIlwain, +22 more
- 13 Jan 2012 - 
TL;DR: iRhom2 is identified as a regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense and was critical for TACE maturation and trafficking to the cell surface in hematopoietic cells.