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Adrián Esteban-Arranz

Bio: Adrián Esteban-Arranz is an academic researcher from University of Castilla–La Mancha. The author has contributed to research in topics: Adsorption & Oxide. The author has an hindex of 4, co-authored 10 publications receiving 62 citations. Previous affiliations of Adrián Esteban-Arranz include National University of Distance Education & University of Manchester.

Papers
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TL;DR: The obtained results show a transcriptional alteration of some genes included in this study, indicating that different cell processes are affected and providing one the first evidences in the mechanisms of action of MWCNT in invertebrates to prevent future damage to aquatic ecosystems.

30 citations

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TL;DR: This study underlines the potential of non-surface modified GO flakes to act as 2D siRNA delivery platforms, without the need for cationic functionalization, but warrants further vector optimization to allow the effective release of the nucleic acid and achieve efficient gene silencing.
Abstract: The development of efficient and safe nucleic acid delivery vectors remains an unmet need holding back translation of gene therapy approaches to the bedside. Graphene oxide (GO) could help bypass such bottlenecks, thanks to its large surface area, versatile chemistry and biocompatibility, which could overall enhance transfection efficiency while abolishing some of the limitations linked to the use of viral vectors. Here, we aimed to assess the capacity of bare GO, without any further surface modification, to complex a short double-stranded nucleic acid of biological relevance (siRNA) and mediate its intracellular delivery. GO formed stable complexes with siRNA at 10 : 1, 20 : 1 and 50 : 1 GO : siRNA mass ratios. Complexation was further corroborated by atomistic molecular dynamics simulations. GO : siRNA complexes were promptly internalized in a primary mouse cell culture, as early as 4 h after exposure. At this time point, intracellular siRNA levels were comparable to those provided by a lipid-based transfection reagent that achieved significant gene silencing. The time-lapse tracking of internalized GO and siRNA evidenced a sharp decrease of intracellular siRNA from 4 to 12 h, while GO was sequestered in large vesicles, which may explain the lack of biological effects (i.e. gene silencing) achieved by GO : siRNA complexes. This study underlines the potential of non-surface modified GO flakes to act as 2D siRNA delivery platforms, without the need for cationic functionalization, but warrants further vector optimization to allow the effective release of the nucleic acid and achieve efficient gene silencing.

29 citations

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TL;DR: In this paper, two different graphene oxides, two reduced graphene oxide under inert atmosphere and one reduced graphene oxide under ammonia atmosphere were used as adsorbents for removing two chloroaromatic compounds from water.

17 citations

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TL;DR: Hydroxyethyl cellulose alumina-based aerogels synthesized by an environmentally friendly freeze-drying process are used as sorbents for oil spills and it is demonstrated that the oil retention coefficient depends on the viscosity of the oil and the amount of hydroxy methyl cellulose contained in the aerogel.

16 citations

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TL;DR: In this paper, a low cost-biomass, olive stone, was used as a carbon precursor to synthesize activated biochar, and experiments were carried by single step activation for two agents (steam and CO2) using a bench scale high-pressure thermobalance.
Abstract: A low cost-biomass, olive stone, was used as a carbon precursor to synthesize activated biochar. Experiments were carried by single step activation for two agents (steam and CO2) using a bench scale high-pressure thermobalance. Temperature, pressure, flow rate and holding time were optimized according to the highest adsorption capacity of the biochar obtained. In this respect, activation conditions were established at 900 °C for 30 min, at 0.15 ml/min and 1 bar for H2O activation. The optimum activation conditions for CO2 activation was found to be 1000 °C for 30 min, at 300 ml/min and 1 bar. The activated biochars yielded were characterized by adsorption-desorption of N2 at −196 °C, scanning electron microscopy, Raman spectroscopy, thermogravimetric analyses and elemental analyses. Results showed that the CO2 activation only generated microporosity developed in the biochar, whereas both meso and micropores were created after steam activation. Then, the optimum materials were evaluated as a possible CO2 adsorbent and for this purpose, the CO2 adsorption isotherms over the pressure range of 1–20 bar at 30 °C were studied. Moreover, the results for these isotherms results were fitted to Langmuir, Freundlich and Sips isotherm models, and the latter forecast the results most accurately.

12 citations


Cited by
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TL;DR: This work systematically describes the toxicity of carbon nanotubes, graphene, GRA and C60 to cells, animals, humans, and microorganisms and has prospects for the limitations of CNM degradation under non-experimental conditions and their potential application.

215 citations

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TL;DR: In this article, the authors discuss biological barriers to cancer nanomedicines and elaborate on two directions that the field is currently exploring to meet its initial expectations: re-engineering and leveraging these obstacles into out-of-the-box diagnostic and therapeutic applications for cancer and beyond.
Abstract: Cancer nanomedicines were initially envisioned as magic bullets, travelling through the circulation to target tumours while sparing healthy tissues the toxicity of classic chemotherapy. While a limited number of nanomedicine therapies have resulted, the disappointing news is that major obstacles were overlooked in the nanoparticle's journey. However, some of these challenges may be turned into opportunities. Here, we discuss biological barriers to cancer nanomedicines and elaborate on two directions that the field is currently exploring to meet its initial expectations. The first strategy entails re-engineering cancer nanomedicines to prevent undesired interactions en route to the tumour. The second aims instead to leverage these obstacles into out-of-the-box diagnostic and therapeutic applications of nanomedicines, for cancer and beyond. Both paths require, among other developments, a deeper understanding of nano-bio interactions. We offer a forward look at how classic cancer nanomedicine may overcome its limitations while contributing to other areas of research.

123 citations

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TL;DR: In this article, metal-organic frameworks (MOFs) are used for the detection and adsorption of selected pesticides that are classified as persistent organic pollutants (POPs) according to the Stockholm Convention.

91 citations

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TL;DR: This review performs a wide literature analysis to present the main and latest advances in the optimal design and characterization of carbon nanotubes with biomedical applications, and their capacities in different areas of preclinical research.
Abstract: Nowadays, biomaterials have become a crucial element in numerous biomedical, preclinical, and clinical applications. The use of nanoparticles entails a great potential in these fields mainly because of the high ratio of surface atoms that modify the physicochemical properties and increases the chemical reactivity. Among them, carbon nanotubes (CNTs) have emerged as a powerful tool to improve biomedical approaches in the management of numerous diseases. CNTs have an excellent ability to penetrate cell membranes, and the sp2 hybridization of all carbons enables their functionalization with almost every biomolecule or compound, allowing them to target cells and deliver drugs under the appropriate environmental stimuli. Besides, in the new promising field of artificial biomaterial generation, nanotubes are studied as the load in nanocomposite materials, improving their mechanical and electrical properties, or even for direct use as scaffolds in body tissue manufacturing. Nevertheless, despite their beneficial contributions, some major concerns need to be solved to boost the clinical development of CNTs, including poor solubility in water, low biodegradability and dispersivity, and toxicity problems associated with CNTs’ interaction with biomolecules in tissues and organs, including the possible effects in the proteome and genome. This review performs a wide literature analysis to present the main and latest advances in the optimal design and characterization of carbon nanotubes with biomedical applications, and their capacities in different areas of preclinical research.

85 citations