Adrian G. Zucco

TL;DR: A genome-wide screen for associations of single-nucleotide polymorphisms to viral load in antiretroviral therapy-naive participants with varying demographics from the START trial identified several HLA alleles significantly associated with VL, extending prior observations that the MHC I is a major host determinant of HIV-1 control.

TL;DR: In this paper, the association between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV+ ART-naive clinical trial participants was tested for associations between HLA alleles and HIV variants, using generalized linear models with Bonferroni correction.

TL;DR: Post-discharge readmission and mortality rates were substantial and sustained recovery should be favored to recovery outcomes in clinical COVID-19 trials, suggesting a 28-day follow-up period may be too short the critically ill.

TL;DR: In this paper , a total of 577 fecal samples from 233 heavily antibiotic-treated transplant patients were examined using high-resolution prescription data and shotgun metagenomics, and the 13 most frequently used antibiotics were significantly associated with 154 (40% of tested associations) microbiome features.

TL;DR: In this paper, a machine learning model was trained to predict mortality within 12 weeks of the first positive SARS-CoV-2 test, which can aid clinicians to implement precision medicine.