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Afif Hentati
Researcher at NorthShore University HealthSystem
Publications - 26
Citations - 7797
Afif Hentati is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Locus (genetics) & Gene. The author has an hindex of 18, co-authored 26 publications receiving 7484 citations. Previous affiliations of Afif Hentati include University of Chicago & Northwestern University.
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Journal ArticleDOI
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.
Mark E. Gurney,Haifeng Pu,Arlene Y. Chiu,Mauro C. Dal Canto,Cynthia Y. Polchow,Denise D. Alexander,Jan Caliendo,Afif Hentati,Young W. Kwon,Han Xiang Deng,W. Chen,Ping Zhai,Robert L. Sufit,Teepu Siddique +13 more
TL;DR: In this article, the authors found that mutations of human Cu,Zn superoxide dismutase (SOD) contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS).
Journal ArticleDOI
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
Han Xiang Deng,Afif Hentati,John A. Tainer,Zafar Iqbal,Annarueber Cayabyab,Wu Yen Hung,Elizabeth D. Getzoff,Ping Hu,Brian Herzfeldt,Raymond P. Roos,Carolyn Warner,Gang Deng,Edwin Soriano,Celestine Smyth,Hans E. Parge,Aftab Ahmed,Allen D. Roses,Robert A. Hallewell,Margaret A. Pericak-Vance,Teepu Siddique +19 more
TL;DR: In this article, single-site mutants in the Cu,Zn superoxide dismutase (SOD) gene occur in patients with the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis.
Journal ArticleDOI
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.
Yi Yang,Afif Hentati,Han Xiang Deng,Omar Dabbagh,Toru Sasaki,Makito Hirano,Wu Yen Hung,Karim Ouahchi,Jianhua Yan,Anser C. Azim,N. Cole,Generoso G. Gascon,Ayesha Yagmour,Mongi Ben-Hamida,Margaret A. Pericak-Vance,Fayçal Hentati,Teepu Siddique +16 more
TL;DR: The predicted sequence of the protein (alsin) may indicate a mechanism for motor-neuron degeneration, as it may include several cell-signaling motifs with known functions, including three associated with guanine-nucleotide exchange factors for GTPases (GEFs).
Journal ArticleDOI
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33–q35
Afif Hentati,Khemissa Bejaoui,Margaret A. Pericak-Vance,Fayçal Hentati,Marcy C. Speer,Wu Yen Hung,Denise A. Figlewicz,Jonathan L. Haines,Jackie B. Rimmler,Christiane Ben Hamida,Mongi Ben Hamida,Robert H. Brown,Teepu Siddique +12 more
TL;DR: To localize the gene for one of the autosomal recessive forms of ALS, linkage analysis to a large inbred family from Tunisia suggested that the ALS2 locus lies in the 8 cM segment flanked by D2S755 and D2 S775.
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Hereditary Spastic Paraplegia Advances in Genetic Research
John K. Fink,Terry Heiman-Patterson,Thomas D. Bird,Franca Cambi,Marie-Pierre Dubé,Denise A. Figlewicz,Jonathan L. Haines,Afif Hentati,Margaret A. Pericak-Vance,W. Raskind,Guy A. Rouleau,Teepu Siddique +11 more
TL;DR: Clinical, genetic, and pathologic features of HSP are reviewed and differential diagnosis and diagnostic criteria of this important group of disorders are presented and polymorphic microsatellite markers useful for genetic linkage analysis and genetic counseling are discussed.