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AG Oomen
Researcher at Centre for Health Protection
Publications - 11
Citations - 696
AG Oomen is an academic researcher from Centre for Health Protection. The author has contributed to research in topics: Inhalation & Silver nanoparticle. The author has an hindex of 5, co-authored 11 publications receiving 554 citations.
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Journal ArticleDOI
The kinetics of the tissue distribution of silver nanoparticles of different sizes.
Danille P K Lankveld,AG Oomen,Petra Krystek,Arianne M. Neigh,A. Troost de Jong,Cornelle W. Noorlander,J. C H Van Eijkeren,Geertsma Re,W.H. de Jong +8 more
TL;DR: A physiologically based pharmacokinetic model for nanoparticles which describes the kinetics of silver nanoparticles was developed and resulted in accumulation in liver, lung and spleen, indicating that these organs may be potential target organs for toxicity after repeated exposure.
Journal ArticleDOI
Detection of titanium particles in human liver and spleen and possible health implications.
Minne B. Heringa,Ruud J. B. Peters,Ronald L. A. W. Bleys,M. K. van der Lee,Peter C. Tromp,P. C. E. van Kesteren,J. C. H. van Eijkeren,Anna K. Undas,AG Oomen,Hans Bouwmeester +9 more
TL;DR: These results prove that TiO2 particles are present in human liver and spleen, with ≥24% of nanosize (< 100 nm).
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Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study
Hedwig M. Braakhuis,Flemming R. Cassee,Paul H. B. Fokkens,Liset J.J. de la Fonteyne,AG Oomen,Petra Krystek,Wim H. de Jong,Henk Van Loveren,Margriet V. D. Z. Park +8 more
TL;DR: The study indicates that using the particle surface area as a dose metric in the alveoli, the dose–response effects of the different silver particle sizes overlap for most pulmonary toxicity parameters.
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An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure.
Hedwig M. Braakhuis,Fiona Murphy,Lan Ma-Hock,Susan Dekkers,Johannes G. Keller,AG Oomen,Vicki Stone +6 more
TL;DR: The GRACIOUS hypotheses and tailored IATA for respiratory toxicity of inhaled NFs can be used to support decision making regarding Safe(r)-by-Design product development or adoption of precautionary measures to mitigate potential risks.
Journal ArticleDOI
Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study
Hedwig M. Braakhuis,Flemming R. Cassee,Paul H. B. Fokkens,L.J. de la Fonteyne,AG Oomen,Petra Krystek,W.H. de Jong,H. van Loveren,Margriet V. D. Z. Park +8 more