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Agne Antanaviciute
Researcher at Medical Research Council
Publications - 41
Citations - 2027
Agne Antanaviciute is an academic researcher from Medical Research Council. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 14, co-authored 34 publications receiving 881 citations. Previous affiliations of Agne Antanaviciute include John Radcliffe Hospital & University of Leeds.
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Journal ArticleDOI
Colonic epithelial cell diversity in health and inflammatory bowel disease
Kaushal Parikh,Kaushal Parikh,Agne Antanaviciute,Agne Antanaviciute,David Fawkner-Corbett,David Fawkner-Corbett,David Fawkner-Corbett,Marta Jagielowicz,Marta Jagielowicz,Anna Aulicino,Anna Aulicino,Christoffer Lagerholm,Simon J. Davis,James Kinchen,James Kinchen,Hannah H. Chen,Hannah H. Chen,Nasullah Khalid Alham,Neil Ashley,Errin Johnson,Philip Hublitz,Leyuan Bao,Leyuan Bao,Joanna Lukomska,Joanna Lukomska,Rajinder Singh Andev,Rajinder Singh Andev,Elisabet Björklund,Elisabet Björklund,Benedikt M. Kessler,Roman Fischer,Robert D. Goldin,Hashem Koohy,Alison Simmons,Alison Simmons +34 more
TL;DR: Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.
Journal ArticleDOI
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease
James Kinchen,Hannah Chen,Kaushal Parikh,Agne Antanaviciute,Marta Jagielowicz,David Fawkner-Corbett,Neil Ashley,Laura Cubitt,Esther Mellado-Gomez,Moustafa Attar,Eshita Sharma,Quin F. Wills,Rory Bowden,Felix Richter,David Ahern,Kamal D. Puri,Jill Henault,Francois Gervais,Hashem Koohy,Alison Simmons +19 more
TL;DR: This work defines how the colonic mesenchyme remodels to fuel inflammation and barrier dysfunction in IBD.
Journal ArticleDOI
Spatiotemporal analysis of human intestinal development at single-cell resolution
David Fawkner-Corbett,Agne Antanaviciute,Kaushal Parikh,Marta Jagielowicz,Marta Jagielowicz,A S Gerós,A S Gerós,Tarun Gupta,Tarun Gupta,Neil Ashley,Doran Khamis,Darren J. Fowler,Edward Morrissey,C Cunningham,Johnson Prv.,Hashem Koohy,Hashem Koohy,Alison Simmons,Alison Simmons +18 more
TL;DR: In this paper, single-cell RNA sequencing and spatial transcriptomics were used to characterize intestinal morphogenesis through time and identify 101 cell states including epithelial and mesenchymal progenitor populations and programs linked to key morphogenetic milestones.
Journal ArticleDOI
Amelogenesis Imperfecta; Genes, Proteins, and Pathways.
Claire E. L. Smith,James A. Poulter,Agne Antanaviciute,Jennifer Kirkham,Steven J. Brookes,Chris F. Inglehearn,Alan J. Mighell,Alan J. Mighell +7 more
TL;DR: The genes and mutations underlying AI presenting in isolation of other health problems, the proteins they encode and knowledge of their roles in amelogenesis are reviewed, combining evidence from human phenotypes, inheritance patterns, mouse models, and in vitro studies.
Journal ArticleDOI
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis
Daniele Corridoni,Daniele Corridoni,Agne Antanaviciute,Agne Antanaviciute,Tarun Gupta,Tarun Gupta,David Fawkner-Corbett,David Fawkner-Corbett,Anna Aulicino,Anna Aulicino,Marta Jagielowicz,Marta Jagielowicz,Kaushal Parikh,Kaushal Parikh,Emmanouela Repapi,Steve Taylor,Dai Ishikawa,Ryo Hatano,Taketo Yamada,Wei Xin,Hubert Slawinski,Rory Bowden,Giorgio Napolitani,Oliver Brain,Chikao Morimoto,Hashem Koohy,Hashem Koohy,Alison Simmons,Alison Simmons +28 more
TL;DR: An unbiased atlas of human colonic CD8+ T cell phenotypes in health and ulcerative colitis is compiled using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry to identify and characterize terminally differentiated dysfunctional UC CD8 + T cells expressing IL-26.