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Agnieszka Bzowska
Researcher at University of Warsaw
Publications - 111
Citations - 2123
Agnieszka Bzowska is an academic researcher from University of Warsaw. The author has contributed to research in topics: Purine nucleoside phosphorylase & Phosphorolysis. The author has an hindex of 23, co-authored 108 publications receiving 1972 citations. Previous affiliations of Agnieszka Bzowska include Tokyo University of Pharmacy and Life Sciences.
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Journal ArticleDOI
Purine nucleoside phosphorylases: properties, functions, and clinical aspects.
TL;DR: Detailed accounts are presented of design of potent inhibitors, largely nucleosides and acyclonucleosides, their phosphates and phosphonates, particularly of the human erythrocyte enzyme intended for induction of the immunodeficient state for clinical applications, such as prevention of host-versus-graft response in organ transplantations.
Journal ArticleDOI
Properties of two unusual, and fluorescent, substrates of purine-nucleoside phosphorylase: 7-methylguanosine and 7-methylinosine.
TL;DR: Measurements of pH-dependence of kinetic constants indicated that the cationic forms are the preferred substrates, whereas the monoanion of inosine appears to be almost as good a substrate as the neutral form.
Journal ArticleDOI
Crystal structure of the ternary complex of E. coli purine nucleoside phosphorylase with formycin B, a structural analogue of the substrate inosine, and phosphate (Sulphate) at 2.1 A resolution.
TL;DR: The ternary complex of purine nucleoside phosphorylase from E. coli with formycin B and a sulphate or phosphate ion crystallized in the hexagonal space group P6122 contains a biologically active hexamer formed through 2-fold crystallographic symmetry, constituting a trimer of dimers.
Journal ArticleDOI
A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation
Huaying Zhao,Rodolfo Ghirlando,Carlos Alfonso,Fumio Arisaka,Ilan Attali,David L. Bain,Marina Bakhtina,Donald F. Becker,Gregory J. Bedwell,Ahmet Bekdemir,Tabot M. D. Besong,Tabot M. D. Besong,Catherine Birck,Chad A. Brautigam,William Brennerman,Olwyn Byron,Agnieszka Bzowska,Jonathan B. Chaires,Catherine T. Chaton,Helmut Cölfen,Keith D. Connaghan,Kimberly A. Crowley,Ute Curth,Tina Daviter,William L. Dean,Ana I. Díez,Christine Ebel,Christine Ebel,Debra M. Eckert,Leslie E. Eisele,Edward Eisenstein,Patrick England,Carlos R. Escalante,Jeffrey A. Fagan,Robert Fairman,Ron M. Finn,Wolfgang Fischle,José García de la Torre,Jayesh Gor,Henning Gustafsson,Damien Hall,Stephen E. Harding,José G. Hernández Cifre,Andrew B. Herr,Andrew B. Herr,Elizabeth E. Howell,Richard Stefan Isaac,Shu-Chuan Jao,Davis Jose,Soon-Jong Kim,Bashkim Kokona,Jack A. Kornblatt,Dalibor Kosek,Elena Krayukhina,Daniel D Krzizike,Eric Kusznir,Hyewon Kwon,Adam G. Larson,Thomas M. Laue,Aline Le Roy,Aline Le Roy,Andrew P. Leech,Hauke Lilie,Karolin Luger,Juan Román Luque-Ortega,Jia Ma,Carrie A. May,Ernest L. Maynard,Anna Modrak-Wójcik,Yee-Foong Mok,Norbert Mücke,Luitgard Nagel-Steger,Geeta J. Narlikar,Masanori Noda,Amanda Nourse,Tomas Obsil,Chad K. Park,Jin Ku Park,Peter D. Pawelek,Erby E. Perdue,Stephen J. Perkins,Matthew A. Perugini,Craig L. Peterson,Martin G. Peverelli,Grzegorz Piszczek,Gali Prag,Peter E. Prevelige,Bertrand Raynal,Lenka Rezabkova,Klaus Richter,Alison E. Ringel,Rose Rosenberg,Arthur J. Rowe,Arne C. Rufer,David J. Scott,Javier Seravalli,Alexandra S. Solovyova,Renjie Song,David Staunton,Caitlin I. Stoddard,Katherine Stott,Holger M. Strauss,Werner Streicher,John P. Sumida,Sarah G. Swygert,Roman H. Szczepanowski,Ingrid Tessmer,Ronald T. Toth,Ashutosh Tripathy,Susumu Uchiyama,Stephan Uebel,Satoru Unzai,Anna Vitlin Gruber,Peter H. von Hippel,Christine Wandrey,Szu Huan Wang,Steven E. Weitzel,Beata Wielgus-Kutrowska,Cynthia Wolberger,Martin Wolff,Edward Wright,Yu Sung Wu,Jacinta M. Wubben,Peter Schuck +123 more
TL;DR: A multi-laboratory study to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques highlights the necessity and effectiveness of independent calibration of basic AUC data dimensions for reliable quantitative studies.
Journal ArticleDOI
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 A resolution.
TL;DR: Trimeric calf spleen purine nucleoside phosphorylase isolated form human tissues is a primary target for chemotherapeutic intervention, and the more stable calf enzyme has similar physico-chemical and kinetic properties, as well as response to inhibitors.