Author
Agustín Sánchez
Bio: Agustín Sánchez is an academic researcher from University of Santiago de Compostela. The author has contributed to research in topics: Crystal structure & Nuclear magnetic resonance spectroscopy. The author has an hindex of 29, co-authored 143 publications receiving 2607 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: In this article, the reaction of phenylmercury(II) acetate with a series of alkyl, aryl and heterocyclic thiosemicarbazones in ethanol formed novel phenylmerscury derivatives of stoichiometry, characterised with the help of analytical data, physical properties, IR, far-IR, multinuclear NMR (1H, 13C, 199Hg) spectroscopy and X-ray crystallography of complexes 1, 5 and 6.
Abstract: The reactions of phenylmercury(II) acetate with a series of alkyl, aryl and heterocyclic thiosemicarbazones in ethanol formed novel phenylmercury(II) derivatives of stoichiometry [HgPhL] [HL = RN3N2HC1(S)N1H2 = cyclopentanone 1, cyclohexanone 2, benzaldehyde 3, 2-hydroxybenzaldehyde 4, 4-methoxybenzaldehyde 5, pyrrole-2-carbaldehyde 6, thiophene-2-carbaldehyde 7 or furan-2-carbaldehyde 8 thiosemicarbazone], characterised with the help of analytical data, physical properties, IR, far-IR, multinuclear NMR (1H, 13C, 199Hg) spectroscopy and X-ray crystallography of complexes 1, 5 and 6. The 1H and 13C NMR data suggest that the N2H group is deprotonated during reaction with phenylmercury(II) acetate and co-ordination occurs via the N3,S atoms in a chelating mode. The 199Hg NMR data suggest symmetrisation phenomenon for complexes 3 and 5, 2[HgPhL] ⇌ HgPh2 + [HgL], which is supported also by 1H and 13C NMR data. The δ(Hg) values reveal that shielding of Hg with the change of organic group in the thiosemicarbazones decreases in the order: 2-hydroxybenzene ⋙ furan > benzene > 4-methoxybenzene thiophene ≈ cyclohexanone ≈ cyclopentanone > pyrrole and the Lewis basicity of the thiosemicarbazones varies in the opposite order. The 1H and 13C NMR data reveal that 7 and 8 show isomerism. There are two strong [Hg–C 2.063(7) 1, 2.069(10) 5, 2.049(11) 6; Hg–S 2.382(2) 1, 2.357(3) 5, 2.377(3) A 6] and one weak bond [Hg–N3 2.489(6) 1, 2.611(7) 5, 2.492(9) A 6], with CPh–Hg–S bond angles of 162.9(2), 174.2(3), 165.8(3)° respectively. The weak intermolecular interactions via Hg · · · N2 [3.001(6) A] in 1 and via Hg · · · S in 5 [3.518(3) A] and 6 [3.528(3) A] form centrosymmetric dimers and Hg formally acquires four-co-ordination with two strong (Hg–C, Hg–S), one weak (Hg · · · N3) and one secondary (Hg · · · N2 or S) bonds. The preferred dimer formation via N2 nitrogen in 1, rather than via sulfur atoms (5 and 6) despite Hg · · · S affinity represents an unusual bonding mode. From the low-temperature 1H NMR studies of some selected complexes, the energy barrier (ΔGTc*, Tc is coalescence temperature) to rotation of the amino group about the C1–N1 bond was calculated and correlated with bonding parameters of the thioamide group in the solid state.
101 citations
TL;DR: In this article, the coordination modes of 5-pyrazolones are reviewed in light of the available X-ray diffraction studies of their complexes, and the coordination behavior of the molecules without any donor atoms other than those associated with the pyrazolone ring is discussed.
100 citations
TL;DR: The in vitro antitumoral assays performed with two HL ligands and their metal complexes showed significant cytostatic activity for the latter, with the most active [ML2] derivative being about sixteen times more active than cis-DDP against the cisplatinum-resistant cell line A2780cisR.
88 citations
TL;DR: The title compound was prepared from 1-methyl-2(3H)-inidazolinethione and triphenyltin(IV) hydroxide, and its crystal structure was determined by X-ray diffraction.
75 citations
TL;DR: This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S and showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis.
61 citations
Cited by
More filters
1,256 citations
1,133 citations
TL;DR: The state of the art in the field of antimicrobial polymeric systems during the last decade is described in this paper, where a classification of the different materials is carried out dividing basically those synthetic polymers that exhibit antimicrobial activity by themselves; those whose biocidal activity is conferred through their chemical modification; those that incorporate antimicrobial organic compounds with either low or high molecular weight; and those that involve the addition of active inorganic systems.
1,063 citations
TL;DR: Recently accumulated experimental evidence for aurophilic interactions in and between molecular gold(I) compounds and the results of pertinent theoretical calculations are reviewed and new experimental and theoretical findings are related to earlier observations.
Abstract: Recently accumulated experimental evidence for aurophilic interactions in and between molecular gold(I) compounds and the results of pertinent theoretical calculations are reviewed for the period from 2007 to mid-2011. The influence of the intra- and intermolecular bonding contacts between the closed-shell metal centres, Au–Au, on the molecular and crystal structures, and the consequences of these effects for the chemical and physical properties of gold compounds are summarized for the various classes of mono- and polynuclear systems. The literature survey builds on the contents of previous reviews and relates new experimental and theoretical findings to earlier observations (353 references).
862 citations
TL;DR: The spectrum of gold complexes described as antiproliferative compounds comprises a broad variety of different species including many phosphine complexes as well as gold in different oxidation states.
700 citations