A
Ahmed F. Darweesh
Researcher at Cairo University
Publications - 43
Citations - 563
Ahmed F. Darweesh is an academic researcher from Cairo University. The author has contributed to research in topics: Benzothiazole & Pyrazole. The author has an hindex of 12, co-authored 43 publications receiving 419 citations.
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Molecular docking simulation and anticancer assessment on human breast carcinoma cell line using novel bis(1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile) and bis(1,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-b]pyridine-6-carbonitrile) derivatives.
TL;DR: An efficient route for the synthesis of novel bis(1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile) derivatives is reported and indicated the best binding mode compared to the standard ligand sorafenib.
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Synthesis, characterization and antitumor activity of novel tetrapodal 1,4-dihydropyridines: p53 induction, cell cycle arrest and low damage effect on normal cells induced by genotoxic factor H2O2
TL;DR: Compound 5b has been found to reduce apoptosis of human normal melanocytes HFB4 and normal fibroblasts BHK that has been treated with genotoxic factor H2O2 and has a potent protective effect against DNA damage, as indicated by the in vitro studying of different concentrations of 5b against two different types of healthy DNA.
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Microwave Assisted Green Multicomponent Synthesis of Novel bis(2‐Amino‐tetrahydro‐4H‐chromene‐3‐carbonitrile) Derivatives Using Chitosan as Eco‐friendly Basic Catalyst
TL;DR: In this paper, a simple, efficient, and eco-friendly procedure was developed for the synthesis of bis(4H-chromene-3-carbonitrile) derivatives using chitosan as catalyst under microwave-assisted reaction conditions.
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Synthesis and characterization of poly(2,6-dimethyl-4-phenyl-1,4-dihydropyridinyl)arenes as novel multi-armed molecules
TL;DR: In this paper, a series of poly(2,6-dimethyl-4-phenyl-1,4-dihydropyridinyl)arenes were synthesized in good yields using a one-pot, acid-catalyzed cyclocondensation reaction of the appropriate poly(aldehydes) with 3-aminobut-2-enenitrile in acetic acid at reflux.
Journal ArticleDOI
Experimental and theoretical study on the regioselective bis- and polyalkylation of 2-mercaptonicotinonitrile and 2-mercaptopyrimidine-5-carbonitrile derivatives
Nesma A. Abd El-Fatah,Ahmed F. Darweesh,Adel A. Mohamed,Ismail A. Abdelhamid,Ahmed H. M. Elwahy +4 more
TL;DR: In this paper, the utility of 2-mercaptonicotinonitriles 3 and 4, as well as poly(pyridines) via alkylation with the corresponding bis- and poy(halo) compounds was investigated.